Ignite Creation Date:
2024-05-06 @ 8:12 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06293664
Status:
RECRUITING
Last Update Posted:
2024-03-05
First Post:
2024-02-28
Brief Title:
Protocol for Alpha MSH Infusion Study in Patients With Type 2 Diabetes
Sponsor:
Dasman Diabetes Institute
Organization:
Dasman Diabetes Institute
Study Overview
Official Title:
Randomized Cross-over Designed Study of the Physiological Impact of Alpha MSH on Glycemic Response to an Oral Glucose Tolerance Test in Patients With Type 2 Diabetes
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
α-MSH T2DM
Brief Summary:
Alpha-melanocyte stimulatory hormone α-MSH is a melanocyte-stimulating hormone produced by the hypothalamus and released from the pituitary gland It acts as an agonist to the melanocortin 5 receptor MC5R in human skeletal muscle playing a role in glucose uptake and disposal This study aims to investigate whether α-MSH can enhance glucose tolerance in patients with Type 2 Diabetes Mellitus T2DM
Detailed Description:
Pre-clinical studies in mice have shown improved glucose clearance with α-MSH infusion particularly in skeletal muscle Research has demonstrated that α-MSH improves glucose tolerance in healthy humans by promoting glucose uptake in skeletal muscle cells
Therefore this study seeks to answer the question of whether alpha-MSH improves glucose tolerance in patients with T2DM This will be addressed through measuring the impact of α-MSH infusion in patients with T2DM The research involves a double-blinded randomized placebo-controlled crossover study
Therefore this study seeks to answer the question of whether alpha-MSH improves glucose tolerance in patients with T2DM This will be addressed through measuring the impact of α-MSH infusion in patients with T2DM The research involves a double-blinded randomized placebo-controlled crossover study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None