Ignite Creation Date:
2024-05-06 @ 8:13 PM
Last Modification Date:
2024-10-26 @ 3:22 PM
Study NCT ID:
NCT06294418
Status:
RECRUITING
Last Update Posted:
2024-03-05
First Post:
2024-02-26
Brief Title:
FCI in Post-operative Low Grade Gliomas
Sponsor:
NHS Grampian
Organization:
NHS Grampian
Study Overview
Official Title:
Non-invasive In-vivo Characterisation of Postoperative Low Grade Gliomas Using Field Cycling Imaging FCI
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this pilot study is to explore the utility of a new imaging technique called Field Cycling Imaging FCI in postoperative low grade gliomas
The main question it aims to answer is if FCI can differentiate subtypes of low grade gliomas Participants will have one FCI scan
The main question it aims to answer is if FCI can differentiate subtypes of low grade gliomas Participants will have one FCI scan
Detailed Description:
Standard clinical magnetic resonance imaging MRI is the mainstay of diagnosis in brain lesions It is a powerful imaging technique for the non-invasive investigation of the brain and has been an incredibly successful technology since its commercialisation in the 1980s largely due to its excellent spatial resolution and ability to distinguish multiple tissues in multiple planes When exogenous contrast agents are used MRI can demonstrate the breakdown of the blood-brain barrier and provide additional physiological information
However standard MRI has limitations in determining the subtypes of tumours which originate from different cells and therefore contain differing types of proteins The aim of this project is to establish if there is a difference in the relaxometry ie loss of MRI signal over time characteristics of different brain lesions using Field Cycling Imaging FCI which is a new technology being developed at the University of Aberdeen
FCI combines the use of a moderately high magnetic field with the ability to probe low magnetic fields so that one can preserve image resolution while also exploiting the high contrast present at low magnetic fields This provides quantitative data on the molecular dynamics in the tissues completely non-invasively
For this study the research team will use FCI to try to establish if there is a difference in the relaxometry characteristics of different low-grade gliomas Ten patients with postoperative low grade glioma will be included Each participant will be asked to undergo one FCI scan only FCI images will be acquired on dedicated equipment specifically built for the purpose of imaging human volunteers and patients Participants will carry on receiving their routine clinical care before and after their scan
However standard MRI has limitations in determining the subtypes of tumours which originate from different cells and therefore contain differing types of proteins The aim of this project is to establish if there is a difference in the relaxometry ie loss of MRI signal over time characteristics of different brain lesions using Field Cycling Imaging FCI which is a new technology being developed at the University of Aberdeen
FCI combines the use of a moderately high magnetic field with the ability to probe low magnetic fields so that one can preserve image resolution while also exploiting the high contrast present at low magnetic fields This provides quantitative data on the molecular dynamics in the tissues completely non-invasively
For this study the research team will use FCI to try to establish if there is a difference in the relaxometry characteristics of different low-grade gliomas Ten patients with postoperative low grade glioma will be included Each participant will be asked to undergo one FCI scan only FCI images will be acquired on dedicated equipment specifically built for the purpose of imaging human volunteers and patients Participants will carry on receiving their routine clinical care before and after their scan
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None