Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06303414
Status:
RECRUITING
Last Update Posted:
2024-03-12
First Post:
2024-03-04
Brief Title:
Revascularization for Symptomatic Non-acute Carotid Artery Occlusion
Sponsor:
Xuanwu Hospital Beijing
Organization:
Xuanwu Hospital Beijing
Study Overview
Official Title:
Revascularization for Symptomatic Non-acute Carotid Artery Occlusion
Status:
RECRUITING
Status Verified Date:
2016-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RESCO
Brief Summary:
The short-term and long-term efficacy of recanalization therapy needs to be further confirmed by large-sample prospective studies The comparison of success rate complication rate and efficacy among the three recanalization modalities also needs to be further explored The purpose of this cohort study is to observe the success rate efficacy and safety of recanalization treatment for non-acute occlusion and to further compare the advantages and disadvantages of CEA endovascular intervention and hybrid surgery
Detailed Description:
Carotid artery occlusion is one of the primary causes of ischemic stroke When the occlusion time exceeds 30 days it is commonlly referred to as chronic carotid artery occlusion CCAO and patients with carotid artery occlusion over 24 hours are collectively referred as non-acute occlusion Symptomatic non-acute occlusion patients with definite hemodynamic hypoperfusion still face a high risk of stroke recurrence under drug treatment with recurrence rates reported to be between 123 and 227 within 2 years Currently the surgical methods for the treatment of carotid artery occlusion are mainly divided into extracranial-intracranial EC-IC bypass and recanalization treatment Recanalization treatment includes CEA endovascular intervention and hybrid surgery While the Carotid Occlusion Surgery Study COSS and the recently published Carotid or Middle cerebral artery Occlusion Surgery Study CMOSS failed to reveal the significant advantages of EC-IC bypass surgery over medical treatment for patients with symptomatic artery occlusion combined with hemodynamic insufficiency recanalization treatment has been shown to be a promising treatment modality by case-control studies with small sample size However the short-term and long-term efficacy of recanalization therapy needs to be further confirmed by large-sample prospective studies The comparison of success rate complication rate and efficacy among the three recanalization modalities also needs to be further explored In addition about half of non-acute occlusion patients have cognitive impairment and the role of cerebral hemodynamics in cognitive impairment is still unclear Therefore the purpose of this cohort study is to observe the success rate efficacy and safety of recanalization treatment for non-acute occlusion and to further compare the advantages and disadvantages of CEA endovascular intervention and hybrid surgery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None