Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06301035
Status:
RECRUITING
Last Update Posted:
2024-06-26
First Post:
2024-01-22
Brief Title:
Asymmetric High-flow Nasal Cannula HFNC vs Standard HFNC for Post Extubation High-risk Group
Sponsor:
Samsung Medical Center
Organization:
Samsung Medical Center
Study Overview
Official Title:
Comparison of Asymmetric High-flow Nasal Cannula HFNC and Standard HFNC in Post Extubation High-risk Group A Prospective Single-center Open-labeled Randomized Controlled Pilot Study
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background The exacerbation of respiratory failure that occurs after endotracheal intubation often occurs in patients who have received mechanical ventilation therapy and when it occurs it emerges as an important issue to consider reintubation of endotracheal intubation High-flow nasal cannula HFNC through nasal cannula is known to produce positive airway pressure and deliver a certain amount of oxygen and recently reported clinical studies have demonstrated the effect of lowering the risk of reintubation after endotracheal intubation which is recommended for use in recent clinical practice guidelines However in patients at high risk of intubation failure the combination of high-flow oxygen therapy and non-invasive positive-pressure ventilation therapy rather than the application of high-flow oxygen therapy alone through nasal cannula is helpful in reducing the rate of reintubation of endotracheal intubation However an alternative to non-invasive positive-pressure ventilation therapy is needed as there is a possibility of complications such as aspiration pneumonia maladaptation of the application device mask and discomfort making it difficult to apply it in the field
Recently it has been reported that high flow oxygen therapy through an asymmetric nasal cannula forms sufficient positive pressure in terms of respiratory dynamics which makes the patient feel comfortable and reduces work of breath However no clinical studies have yet compared physiological effects using this method in patients at high risk of extubation failure
Goal The investigators would like to compare the physiological effects of high flow oxygen therapy through asymmetric nasal cannula with high flow oxygen therapy through standard nasal cannula in patients identified as high-risk groups for valvular failure
Hypothesis Asymmetric nasal cannula reduces work of breath compared to standard nasal cannula in high-risk patients with valvular failure
Recently it has been reported that high flow oxygen therapy through an asymmetric nasal cannula forms sufficient positive pressure in terms of respiratory dynamics which makes the patient feel comfortable and reduces work of breath However no clinical studies have yet compared physiological effects using this method in patients at high risk of extubation failure
Goal The investigators would like to compare the physiological effects of high flow oxygen therapy through asymmetric nasal cannula with high flow oxygen therapy through standard nasal cannula in patients identified as high-risk groups for valvular failure
Hypothesis Asymmetric nasal cannula reduces work of breath compared to standard nasal cannula in high-risk patients with valvular failure
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None