Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:23 PM
Study NCT ID:
NCT06304935
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-19
First Post:
2024-03-05
Brief Title:
Injectable Platelet Rich Fibrin Post Tonsillectomy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Effect of the Injectable Platelet Rich Fibrin After Tonsillectomy on Wound Healing Hemostasis and Post Operative Pain
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the effect of injectable Prf on healing hemostasis and pain post tonsillectomy
Detailed Description:
Tonsillectomy is the most common surgical procedure performed by otolaryngologists with or without adenoidectomy 1 The most important complication of tonsillectomy is post-tonsillectomy hemorrhage with potential morbidity and death 2 Also severe pain and wound healing remain major problems that affect patients profoundly after surgery causing a lot of time to return to a regular diet and normal activity 3 Pharmacological drugs are used to control post-tonsillectomy pain but with challenges like insufficiency to control pain the presence of contraindications and the presence of side effects as the antiplatelet effects of NSAIDs lead to increased rates of postoperative hemorrhage4 Growth factors and other mediators released by activated platelets play an important role in tissue regeneration and revascularization Platelet concentrates therefore represent a promising therapeutic tool for tissue regeneration In recent years the effects of platelet-rich fibrin PRF on tissue healing have been addressed in many surgical branches especially for dental implant surgery and plastic surgery5 Injectable platelet-rich fibrin IPRF is a recently developed leukocyte-enriched platelet concentrate which could better assist tissue regeneration and wound healing phenomena Although initially in a liquid phase IPRF forms a dynamic fibrin gel embedding platelets leukocytes type 1 collagen COL1 osteocalcin OC growth factors and providing a slow release of growth factors 6-10
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None