Ignite Creation Date:
2024-05-06 @ 8:15 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06319768
Status:
RECRUITING
Last Update Posted:
2024-03-20
First Post:
2024-02-25
Brief Title:
Efficacy of Intralesional Injection of Pentoxifylline Platelet-Rich Plasma and Combined Pentoxifylline With Platelet-Rich Plasma in Patients With Atrophic Acne Scars
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Efficacy of Intralesional Injection of Pentoxifylline Platelet-Rich Plasma and Combined
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Platelet-rich plasma PRP is an Acne vulgaris is a common chronic inflammatory skin disorder It is the eighth most prevalent disease worldwide with a prevalence of 94 Acne scar is one of the most persistent complications of acne causes marked psychological stress to the patient The process of acne scar formation can be broadly divided into two stages increased tissue formation and loss or damage of tissue corresponding to keloid or hypertrophic scar and atrophic scar respectively
The ultimate severity of acne scars is correlated with acne grade and the delay in treatment of active disease The atrophic scars include three subtypes icepick or V-shaped rolling or M-shaped and boxcar or U-shaped scars Among atrophic scars the ice pick type represents 60-70 the boxcar type represents 20-30 and the rolling type represents 15-25 Salameh and Shumaker 2022 According to the qualitative scarring grading system a macular acne scar type also exists which clinically shows erythematous hyperpigmented or hypopigmented flat marks
autologous blood product containing high concentrations of platelets in a small volume of plasma PRP has been utilized in the treatment of orthopedic musculoskeletal and maxillofacial conditions for many years it has only recently gained popularity in dermatology PRP contains various growth factors including platelet-derived growth factor PDGF transforming growth factor TFG vascular endothelial growth factor VEGF and insulin-like growth factor IGF These growth factors stimulate tissue remodeling and are associated with enhanced healing through the attraction of macrophages upregulation of collagen synthesis and promotion of tissue regeneration Moreover platelet-derived growth factor PDGF was shown to promote wound healing angiogenesis and tissue remodeling
The ultimate severity of acne scars is correlated with acne grade and the delay in treatment of active disease The atrophic scars include three subtypes icepick or V-shaped rolling or M-shaped and boxcar or U-shaped scars Among atrophic scars the ice pick type represents 60-70 the boxcar type represents 20-30 and the rolling type represents 15-25 Salameh and Shumaker 2022 According to the qualitative scarring grading system a macular acne scar type also exists which clinically shows erythematous hyperpigmented or hypopigmented flat marks
autologous blood product containing high concentrations of platelets in a small volume of plasma PRP has been utilized in the treatment of orthopedic musculoskeletal and maxillofacial conditions for many years it has only recently gained popularity in dermatology PRP contains various growth factors including platelet-derived growth factor PDGF transforming growth factor TFG vascular endothelial growth factor VEGF and insulin-like growth factor IGF These growth factors stimulate tissue remodeling and are associated with enhanced healing through the attraction of macrophages upregulation of collagen synthesis and promotion of tissue regeneration Moreover platelet-derived growth factor PDGF was shown to promote wound healing angiogenesis and tissue remodeling
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None