Ignite Creation Date:
2024-05-06 @ 8:16 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06315725
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-16
First Post:
2024-03-12
Brief Title:
Effect of Artificial Sweetener AFS on Glucose Metabolism in Patients With Type 1 Diabetes T1D
Sponsor:
McGill University Health CentreResearch Institute of the McGill University Health Centre
Organization:
McGill University Health CentreResearch Institute of the McGill University Health Centre
Study Overview
Official Title:
A Randomized Cross-Over Study to Investigate the Effect of the Non-Nutritive Sweetener Sucralose on Glucose Metabolism in Patients With Type 1 Diabetes
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AFS_T1D
Brief Summary:
The goal of this randomized crossover study is to test the prediction that consuming carbohydrates will affect insulin release differently depending on whether Non-Nutritive Sweeteners NNSs are consumed simultaneously We aim to determine whether the predicted effects are associated with oral or post-oral sweet taste receptor signaling Our study will focus on patients diagnosed with type 1 diabetes T1D who are using an artificial pancreas AP system as it allows us to monitor glucose and insulin levels over time
Participants will drink four different flavored beverages some with sweet taste blockade and some without in a counter-balanced order They will then rate the sweetness of each beverage and we will collect data from their AP system to monitor insulin and glucose level
To achieve this we will conduct a pilot study to assess the effectiveness and best timing of sweet taste blockade in healthy individuals Insights gained from the pilot study will inform the main study
Sucralose will be used as the NNS maltodextrin as the carbohydrate and Gymnema Sylvestre GS as the sweet taste receptor blocker
Participants will drink four different flavored beverages some with sweet taste blockade and some without in a counter-balanced order They will then rate the sweetness of each beverage and we will collect data from their AP system to monitor insulin and glucose level
To achieve this we will conduct a pilot study to assess the effectiveness and best timing of sweet taste blockade in healthy individuals Insights gained from the pilot study will inform the main study
Sucralose will be used as the NNS maltodextrin as the carbohydrate and Gymnema Sylvestre GS as the sweet taste receptor blocker
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None