Ignite Creation Date:
2024-05-06 @ 8:17 PM
Last Modification Date:
2024-10-26 @ 3:24 PM
Study NCT ID:
NCT06329063
Status:
RECRUITING
Last Update Posted:
2024-04-11
First Post:
2024-03-15
Brief Title:
Oral Vasopressin Modulates Neural Responses to Looming Visual Stimuli An Eye-tracking Study
Sponsor:
University of Electronic Science and Technology of China
Organization:
University of Electronic Science and Technology of China
Study Overview
Official Title:
Vasopressin Modulates Neural Responses to Looming Visual Stimuli An Eye-tracking Study
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main aim of the present study is to investigate the effects of orally administered vasopressin AVP on the perception of time-to-collision of threatening and non-threatening stimuli by combining a validated looming fear eye-tracking paradigm with a randomized between-subject placebo-controlled pharmacological trial design
Detailed Description:
Animal models and initial findings in humans suggest a role of the AVP signaling system in socio-emotional processes At the same time the visual systems remarkable ability to perceive and interpret impending threats notably through the looming phenomenon- a distinct pattern of optical expansion on the retina as objects approach theoretically allows for precise estimation of the time-to-collision TTC It was recently demonstrated that the affective content of looming stimuli influences perceived TTC with threatening objects judged as approaching sooner than non-threatening objects hinting at a nuanced interaction between emotional valence and temporal perception Within this context the present study aims to validate the effects of orally administered on the perception of time-to-collision of threatening and non-threatening stimuli To this end healthy individuals will undergo a double-blind between-subjects placebo-controlled pharmaco-eye-tracking experiment and receive a single oral dose of vasopressin 20 IU or placebo before performing a looming visual stimuli task 45 minutes after administration The task paradigm will encompass threatening butterfly rabbit and non-threatening spider snake stimuli
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None