Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001327
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
1999-11-03
Brief Title:
Establishing the Physiology of Syringomyelia
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Establishing the Physiology of Syringomyelia
Status:
COMPLETED
Status Verified Date:
2011-03-31
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The brain and spinal cord are surrounded by fluid called cerebrospinal fluid CSF The CSF flows through channels in the brain and around the spinal cord Occasionally people are born with malformations of these channels Syringomyelia is a pocket within the CSF channels that results from abnormal CSF flow Syringomyelia is associated with problems in the nervous system Patients with syringomyelia may be unable to detect sensations of pain and heat If the condition is not treated it can worsen
Treatment of this condition is surgical It requires that the flow of CSF is returns to normal There are many different treatment options but no one procedure has been shown to be significantly better than any other
In this study researchers would like to learn more about how the CSF pressure and flow contribute to the progression of syringomyelia Ultrasounds and magnetic resonance imaging MRI will be used to evaluate the anatomy of the brain Researchers hope that information gathered about anatomy and measures of CSF pressure and flow can be used later to develop an optimal surgical treatment for syringomyelia
Treatment of this condition is surgical It requires that the flow of CSF is returns to normal There are many different treatment options but no one procedure has been shown to be significantly better than any other
In this study researchers would like to learn more about how the CSF pressure and flow contribute to the progression of syringomyelia Ultrasounds and magnetic resonance imaging MRI will be used to evaluate the anatomy of the brain Researchers hope that information gathered about anatomy and measures of CSF pressure and flow can be used later to develop an optimal surgical treatment for syringomyelia
Detailed Description:
The purpose of this study is to establish the mechanism of development and progression of syringomyelia Although syringomyelia usually accompanies anatomic abnormalities at the craniocervical junction the pathophysiology that relates these anatomic abnormalities to syringomyelia development and progression is controversial We have been testing the hypothesis that progression of syringomyelia associated with the Chiari I malformation is produced by the cerebellar tonsils partially occluding the subarachnoid space at the foramen magnum and acting as a piston on the partially enclosed spinal subarachnoid space creating enlarged cervical subarachnoid pressure waves which compress the spinal cord from without not from within and propagate syrinx fluid caudally with each heartbeat which leads to syrinx progression We are also testing the hypothesis that development of syringomyelia results from increased transit of CSF through the spinal cord parenchyma and into the syrinx Patients are treated with posterior fossa craniectomy upper cervical laminectomy and duroplasty We evaluate cerebrospinal fluid flow and pressure syrinx size neurologic function and the rate of entrance of CSF into the syrinx before and after surgery These studies and the intraoperative evaluation of the movement of the cerebellar tonsils and the walls of the syrinx are providing data which elucidate the hydrodynamic mechanism of development and progression of syringomyelia
The best treatment for this type of syringomyelia has not been established Present surgical treatment results in disease stabilization in many but not all patients although objective improvement is less common Delayed deterioration is not uncommon Correlation of the anatomic and physiologic measurements should provide data which indicate the mode of development and progression of syringomyelia and which may have implications for the optimal treatment of syringomyelia
The best treatment for this type of syringomyelia has not been established Present surgical treatment results in disease stabilization in many but not all patients although objective improvement is less common Delayed deterioration is not uncommon Correlation of the anatomic and physiologic measurements should provide data which indicate the mode of development and progression of syringomyelia and which may have implications for the optimal treatment of syringomyelia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 92-N-0226 | None | None | None |