Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004332
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
1999-10-18
Brief Title:
Study of the Effect of Growth Hormone-Releasing Hormone Antagonist on Growth Hormone Release in Acromegaly
Sponsor:
National Center for Research Resources NCRR
Organization:
Office of Rare Diseases ORD
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Determine whether release of endogenous growth hormone GH-releasing hormone is involved in GH responses to clonidine pyridostigmine levodopa arginine GH-releasing peptide insulin-induced hypoglycemia and exercise in patients with acromegaly
II Determine whether endogenous GH-releasing hormone influences the maintenance of GH hypersecretion
II Determine whether endogenous GH-releasing hormone influences the maintenance of GH hypersecretion
Detailed Description:
PROTOCOL OUTLINE Growth hormone-releasing hormone antagonist GHRH-A is administered to volunteers and followed with 1 of these challenges insulin clonidine pyridostigmine arginine levodopa growth hormone-releasing peptide or exercise Tests are repeated with normal saline as the control the order of administration control vs pharmacologic stimulation is randomly assigned
Patients receive GHRH-A dose determined in volunteer study thyrotropin-releasing hormone and growth-releasing hormone
All stimulation tests follow an overnight fast
Patients receive GHRH-A dose determined in volunteer study thyrotropin-releasing hormone and growth-releasing hormone
All stimulation tests follow an overnight fast
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UMMC-1016 | None | None | None |