Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06336499
Status:
COMPLETED
Last Update Posted:
2024-03-29
First Post:
2024-03-22
Brief Title:
Risk Stratification of Orbital Tumors Based on MRl and Artificial Intelligence
Sponsor:
Beijing Tongren Hospital
Organization:
Beijing Tongren Hospital
Study Overview
Official Title:
Risk Stratification of Orbital Tumors Based on MRl and Artificial Intelligence
Status:
COMPLETED
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Orbital tumors can be categorized into benign and malignant tumors and there are significant variations in their biological behavior treatment and prognosis This study aims to enhance the accurate diagnosis and risk stratification of orbital tumors using artificial intelligence AI technology and multiparameter magnetic resonance imaging MRI data It further explores the intrinsic relationship between MRI and the differential diagnosis of benign and malignant orbital tumors as well as the pathological subtypes of malignant tumors and Ki-67 expression levels This research aims to aid in guiding personalized diagnosis and treatment decision-making for patients with orbital tumors while promoting the practical application and incorporation of AI technology
Detailed Description:
Although orbital tumors are less common than other eye-related diseases they can be extremely detrimental to patients Not only can they cause physical disfigurement but they can also lead to functional impairments such as diminished vision and restricted eye movement Orbital tumors can be categorized as either benign or malignant and there are significant disparities in their biological behavior treatment approaches outcomes and prognosis which complicates the processes of differential diagnosis and treatment selection For malignant lesions the treatment plans and prognosis of patients vary due to the different pathological types and stages Hence there is a pressing clinical necessity to devise accurate diagnostic methods for orbital tumors Multiparametric magnetic resonance imaging mp-MRI currently stands as the leading non-invasive imaging technique for diagnosing orbital tumors This study is centered on precise diagnosis of orbital tumor risk stratification utilizing artificial intelligence algorithm technology to explore the inherent connection between MRI images and the distinguishing diagnosis of benign and malignant orbital tumors histological types and Ki-67 expression levels of malignant tumors It aims to integrate clinical information and quantitative MRI features to construct prediction models aid in guiding individual diagnosis and treatment decisions for patients with orbital tumors and facilitate the application and advancement of artificial intelligence technology Specifically the research objectives are outlined as follows
1 Establishing a deep learning-based automatic segmentation model for orbital tumors using a multi-sequence MRI dataset from multiple centers thereby reducing the time required for manual delineation and proving beneficial for subsequent analysis
2 Developing a model for identifying malignant and benign orbital tumors using multiple machine learning algorithms combined with multi-sequence MRI dataset with the aim of providing more precise information for distinguishing between these two entities
3 Constructing robust diagnostic models using machine learning or deep learning approaches with quantitative multi-sequence MRI features to identify the histological type and Ki-67 expression levels of malignant orbital tumors with the purpose of enhancing detection rates and accuracy thereby achieving risk stratification for patients with malignant orbital tumors
1 Establishing a deep learning-based automatic segmentation model for orbital tumors using a multi-sequence MRI dataset from multiple centers thereby reducing the time required for manual delineation and proving beneficial for subsequent analysis
2 Developing a model for identifying malignant and benign orbital tumors using multiple machine learning algorithms combined with multi-sequence MRI dataset with the aim of providing more precise information for distinguishing between these two entities
3 Constructing robust diagnostic models using machine learning or deep learning approaches with quantitative multi-sequence MRI features to identify the histological type and Ki-67 expression levels of malignant orbital tumors with the purpose of enhancing detection rates and accuracy thereby achieving risk stratification for patients with malignant orbital tumors
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None