Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06339606
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-24
First Post:
2024-03-15
Brief Title:
Pregnancy Repository
Sponsor:
Sunnybrook Health Sciences Centre
Organization:
Sunnybrook Health Sciences Centre
Study Overview
Official Title:
Repository for Biospecimens From Pregnant Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PR
Brief Summary:
An essential part of clinical research is the availability and accessibility of human biospecimens for the identification of biomarkers new treatments and measurement of response to therapy Proteins RNA and DNA can be extracted and studied as well This is a critical first step in performing many fundamental molecular biology experiments A variety of biospecimens are utilized for research including but not limited to normal and malignant tissues blood and other body fluids
In order to obtain high-quality biospecimens they must be acquired serially stored according to current standards and matched with clinical information for maximum value As such the investigators would like to create a repository of biospecimens collected from pregnant patients who are seen at Mount Sinai Hospital and other research hospitals in Toronto Mount Sinai provides personnel and infrastructure to serve the largest 7500 birthsyear and highest complex Maternity program in Ontario Of the 7500 patients a year at least 2500 are considered high risk pregnancies where theres a possibility of preeclampsia placenta accreta and a host of other complications For this study biological specimens - blood cervical and placental samples - will be collected from these high-risk groups in order to better understand the causes of the underlying conditions
In order to obtain high-quality biospecimens they must be acquired serially stored according to current standards and matched with clinical information for maximum value As such the investigators would like to create a repository of biospecimens collected from pregnant patients who are seen at Mount Sinai Hospital and other research hospitals in Toronto Mount Sinai provides personnel and infrastructure to serve the largest 7500 birthsyear and highest complex Maternity program in Ontario Of the 7500 patients a year at least 2500 are considered high risk pregnancies where theres a possibility of preeclampsia placenta accreta and a host of other complications For this study biological specimens - blood cervical and placental samples - will be collected from these high-risk groups in order to better understand the causes of the underlying conditions
Detailed Description:
The study will be non-interventional and designed for prospective sample collection and concurrent analysis
Primary Objective 1 The primary objective is to provide a mechanism for system-wide patient engagement for banking and sourcing high-quality biologic specimens including tissues and bodily fluids The study will be initiated at 3 sites - Sunnybrook Health Sciences Centre North York General Hospital and MtSinai Hospital - in the hopes of creating a translational research environment where patient data and biospecimens can inform future clinical practice
The aim is to do this by
1 Establishing a comprehensive secure and de-identified registrydatabase that includes current and future cases at high risk for abnormal placentation and healthy controls for comparison with patient consent
2 Comparing cases of suspected abnormal placentation with a control group of women with no evidence of abnormal placentation
Primary Objective 2 Feasibility study that aims to provide preliminary insights into the biological markers and processes associated with abnormal placentation By comparing a larger control group to those experiencing abnormal placentation the investigators seek to understand potential biomarker differences This phase is explorative in nature and is designed to determine the viability of our research approach and generate preliminary data
Secondary Objective The secondary objective is to facilitate research studies with utilization of these biologic specimens including full-scale trials should our initial findings warrant them
The blood samples will be useful in identifying the molecular biomarkers that are indicative of disease while the placental and cervical samples are important to better understand the underlying physiology of perinatal disease The aim is therefore to establish both a clinical database and a bloodtissue bio-bank By more comprehensively understanding the pathophysiology of invasive placentation the goal is to develop high specificity testing modalities perhaps through novel maternal serum biomarkers to aid in diagnosis management and improved outcomes for both mothers and their babies
Patients will be consented during their visit to the hospital and bloodcervical samples will be collected serially at each visit Patient data will be collected from the Electronic Medical Record systems and paper charts and this will be entered into REDCap The biological samples will be sent to Sunnybrook Research Institute for storage
Both blood and tissue specimens will be collected during regular patient visits Biospecimens will be labeled with an anonymous study identifier that will be linked to corresponding clinical data and specimen annotation Specimens will be stored in appropriate temperature and storage conditions before they are transported to Sunnybrook - where the specimens will be stored long-term Specimens that are inadequate for study because of poor cell viability or insufficient tissue will be destroyed
Cervical and blood samples will be taken serially from patients during their regular clinic visits Up to 20 mL of blood and plasma may be collected for research use via venipuncture Efforts will be made to only collect the minimum volume necessary for research use At the patients request the research blood volume may be further reduced Secondly 10 mL of cord blood will be collected after the delivery of the baby from the umbilical vein attached to the placenta Lastly 1-5g samples of placental villous tissue will be collected after delivery from all subjects who have consented to this Removal of these very small amounts of tissue will not interfere with routine histopathological examination conducted in the usual clinical care of subjects All these samples will be labelled with the appropriate study number and kept at Sunnybrook for storage Consent for biospecimen collection will also include permission for future use of their de-identified samples in collaborative projects with other institutions All such collaborative projects would be subject to Ethics Board consent and relevant material transfer agreements
Primary Objective 1 The primary objective is to provide a mechanism for system-wide patient engagement for banking and sourcing high-quality biologic specimens including tissues and bodily fluids The study will be initiated at 3 sites - Sunnybrook Health Sciences Centre North York General Hospital and MtSinai Hospital - in the hopes of creating a translational research environment where patient data and biospecimens can inform future clinical practice
The aim is to do this by
1 Establishing a comprehensive secure and de-identified registrydatabase that includes current and future cases at high risk for abnormal placentation and healthy controls for comparison with patient consent
2 Comparing cases of suspected abnormal placentation with a control group of women with no evidence of abnormal placentation
Primary Objective 2 Feasibility study that aims to provide preliminary insights into the biological markers and processes associated with abnormal placentation By comparing a larger control group to those experiencing abnormal placentation the investigators seek to understand potential biomarker differences This phase is explorative in nature and is designed to determine the viability of our research approach and generate preliminary data
Secondary Objective The secondary objective is to facilitate research studies with utilization of these biologic specimens including full-scale trials should our initial findings warrant them
The blood samples will be useful in identifying the molecular biomarkers that are indicative of disease while the placental and cervical samples are important to better understand the underlying physiology of perinatal disease The aim is therefore to establish both a clinical database and a bloodtissue bio-bank By more comprehensively understanding the pathophysiology of invasive placentation the goal is to develop high specificity testing modalities perhaps through novel maternal serum biomarkers to aid in diagnosis management and improved outcomes for both mothers and their babies
Patients will be consented during their visit to the hospital and bloodcervical samples will be collected serially at each visit Patient data will be collected from the Electronic Medical Record systems and paper charts and this will be entered into REDCap The biological samples will be sent to Sunnybrook Research Institute for storage
Both blood and tissue specimens will be collected during regular patient visits Biospecimens will be labeled with an anonymous study identifier that will be linked to corresponding clinical data and specimen annotation Specimens will be stored in appropriate temperature and storage conditions before they are transported to Sunnybrook - where the specimens will be stored long-term Specimens that are inadequate for study because of poor cell viability or insufficient tissue will be destroyed
Cervical and blood samples will be taken serially from patients during their regular clinic visits Up to 20 mL of blood and plasma may be collected for research use via venipuncture Efforts will be made to only collect the minimum volume necessary for research use At the patients request the research blood volume may be further reduced Secondly 10 mL of cord blood will be collected after the delivery of the baby from the umbilical vein attached to the placenta Lastly 1-5g samples of placental villous tissue will be collected after delivery from all subjects who have consented to this Removal of these very small amounts of tissue will not interfere with routine histopathological examination conducted in the usual clinical care of subjects All these samples will be labelled with the appropriate study number and kept at Sunnybrook for storage Consent for biospecimen collection will also include permission for future use of their de-identified samples in collaborative projects with other institutions All such collaborative projects would be subject to Ethics Board consent and relevant material transfer agreements
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None