Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06338124
Status:
RECRUITING
Last Update Posted:
2024-07-11
First Post:
2024-03-22
Brief Title:
Value of Laboratory Biomarkers in Prediction of Outcome in Septic Patients
Sponsor:
Egymedicalpedia
Organization:
Egymedicalpedia
Study Overview
Official Title:
Value of Laboratory Biomarkers in Prediction of Outcome in Septic Patients
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Sepsis is defined as a dysregulated host response to infection Despite ongoing efforts both the incidence and mortality of sepsis have demonstrated limited reductions over the past yearsThere are several biomarkers that have already been studied for the early diagnosis of sepsis Some of these markers can be used in risk prediction and monitoring the outcome of sepsis
Some of these markers as procalcitonin and CD14 are costly and not feasible options for low- and middle-income countries While other biomarkers are feasible and accessible to be evaluated as Triglycerideglucose index TyG Relative Distributive Width of red blood corpuscles to albumin ratio RAR C-reactive proteinNeutrophile Lympocyte ratio and serum lactate levels
Some of these markers as procalcitonin and CD14 are costly and not feasible options for low- and middle-income countries While other biomarkers are feasible and accessible to be evaluated as Triglycerideglucose index TyG Relative Distributive Width of red blood corpuscles to albumin ratio RAR C-reactive proteinNeutrophile Lympocyte ratio and serum lactate levels
Detailed Description:
Sepsis is defined as a dysregulated host response to infection Despite ongoing efforts both the incidence and mortality of sepsis have demonstrated limited reductions over the past years
There are several biomarkers that have already been studied for the early diagnosis of sepsis Some of these markers can be used in risk prediction and monitoring the outcome of sepsis
Triglyceride-glucose TyG index has emerged as a surrogate marker of insulin resistance which is often prevalent in patients with sepsis Red blood cell distribution width RDW is a common clinical hematology indicator that reflects the heterogeneity of red blood cell size As a simple and inexpensive parameter RDW has been successfully used to predict the prognosis of many diseases including cardiovascular disease kidney disease diabetes mellitus and liver disease
Recent studies have also shown that RDW is significantly associated with the mortality of sepsis RDW to albumin ratio was evaluated as a novel and simple biomarker of inflammation
-C-reactive protein CRP is a sensitive indicator of the body reflecting damage and infection
Serum albumin level drops significantly in the acute stage of infection 16 CRPALB ratio CAR could be a marker to predict mortality in sepsis
The neutrophil-lymphocyte ratio NLR is an-inflammatory biomarker that can be used as an indicator of systemic inflammation It is a simple that does not add costs to complete blood count laboratory examinations which are performed routinely in hospitals It was tested as a guide for the prognosis of various diseases such as cancer community pneumonia and sepsis
Although these various biomarkers that have been proposed no single clinical or biological indicator of sepsis has gained general acceptance And to our knowledge no previous study compared between these indicators in prediction of sepsis outcome or determined the clinical significance of combination of multiple biomarkers in prognosis of sepsis
There are several biomarkers that have already been studied for the early diagnosis of sepsis Some of these markers can be used in risk prediction and monitoring the outcome of sepsis
Triglyceride-glucose TyG index has emerged as a surrogate marker of insulin resistance which is often prevalent in patients with sepsis Red blood cell distribution width RDW is a common clinical hematology indicator that reflects the heterogeneity of red blood cell size As a simple and inexpensive parameter RDW has been successfully used to predict the prognosis of many diseases including cardiovascular disease kidney disease diabetes mellitus and liver disease
Recent studies have also shown that RDW is significantly associated with the mortality of sepsis RDW to albumin ratio was evaluated as a novel and simple biomarker of inflammation
-C-reactive protein CRP is a sensitive indicator of the body reflecting damage and infection
Serum albumin level drops significantly in the acute stage of infection 16 CRPALB ratio CAR could be a marker to predict mortality in sepsis
The neutrophil-lymphocyte ratio NLR is an-inflammatory biomarker that can be used as an indicator of systemic inflammation It is a simple that does not add costs to complete blood count laboratory examinations which are performed routinely in hospitals It was tested as a guide for the prognosis of various diseases such as cancer community pneumonia and sepsis
Although these various biomarkers that have been proposed no single clinical or biological indicator of sepsis has gained general acceptance And to our knowledge no previous study compared between these indicators in prediction of sepsis outcome or determined the clinical significance of combination of multiple biomarkers in prognosis of sepsis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None