Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06334042
Status:
RECRUITING
Last Update Posted:
2024-03-27
First Post:
2024-03-12
Brief Title:
Examination of the Effects of Chromium Levels on Glucose Metabolism Lipid Metabolism Morbidity and Mortality Rates in Patients Followed in Intensive Care Unit
Sponsor:
Oguzhan Kahveci
Organization:
Hacettepe University
Study Overview
Official Title:
Examination of the Effects of Chromium Levels on Glucose Metabolism Lipid Metabolism Morbidity and Mortality Rates in Patients Followed in Intensive Care Unit
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to learn about the effects of chromium serum levels on glucose metabolism lipid metabolism morbidity and mortality rates in critically ill intensive care patients The investigators goal is to provide a different perspective on solving the common problems of hyperglycemia and dyslipidemia encountered in intensive care patients aiming to reduce morbidity and mortality rates
Participants will give a single blood sample into trace element serum tube on the day of admission to the intensive care unit along with routine blood tests and samples will be taken once a week during their stay in the intensive care unit
Participants will give a single blood sample into trace element serum tube on the day of admission to the intensive care unit along with routine blood tests and samples will be taken once a week during their stay in the intensive care unit
Detailed Description:
Hyperglycemia is a common risk factor in critically ill patients admitted to intensive care units increasing hospital stay duration morbiditymortality rates and is associated with increased undesirable cardiovascular events thrombosis inflammatory changes impaired immune functions increased infection frequency delayed wound healing osmotic diuresis fluid - electrolyte imbalances and other issues
Dyslipidemia plays a significant role in the development of atherosclerosis and consequently cardiovascular disease
Chromium Cr is a trace metal It has been claimed that trivalent chromium is a cofactor of a low molecular weight chromium - binding substance LMWCr also known as chromodulin an oligopeptide LMWCr can enhance the action of insulin thereby improving tissue insulin sensitivity and facilitating glucose transport into the cells This hypothesis is supported by observations that chromium deficiency leads to an increase in blood sugar total cholesterol and triglycerides a decrease in high - density lipoproteins HDL and insulin sensitivity
Patients aged 18 and older admitted to the Intensive Care Unit of Hacettepe University Department of Anesthesiology and Reanimation will be included in the study A single blood sample into trace element serum tube will be taken from participants in the study group on the day of admission to the intensive care unit along with routine blood tests and samples will be taken once a week during their stay in the intensive care unit The chromium level in the collected blood samples will be analyzed using inductively coupled plasma - mass spectrometry ICP - MS The laboratory results of the monitored participants will be prospectively recorded in the data collection form and in IBM SPSS
A literature review revealed very few publications on the effects of chromium serum levels on glucose metabolism lipid metabolism morbidity and mortality rates and the existing publications did not include samples of critically ill intensive care patients With this study the investigators aim to contribute to the national and international literature with a large sample of intensive care patients Thus the investigators goal is to provide a different perspective on solving the common problems of hyperglycemia and dyslipidemia encountered in intensive care patients aiming to reduce morbidity and mortality rates
Dyslipidemia plays a significant role in the development of atherosclerosis and consequently cardiovascular disease
Chromium Cr is a trace metal It has been claimed that trivalent chromium is a cofactor of a low molecular weight chromium - binding substance LMWCr also known as chromodulin an oligopeptide LMWCr can enhance the action of insulin thereby improving tissue insulin sensitivity and facilitating glucose transport into the cells This hypothesis is supported by observations that chromium deficiency leads to an increase in blood sugar total cholesterol and triglycerides a decrease in high - density lipoproteins HDL and insulin sensitivity
Patients aged 18 and older admitted to the Intensive Care Unit of Hacettepe University Department of Anesthesiology and Reanimation will be included in the study A single blood sample into trace element serum tube will be taken from participants in the study group on the day of admission to the intensive care unit along with routine blood tests and samples will be taken once a week during their stay in the intensive care unit The chromium level in the collected blood samples will be analyzed using inductively coupled plasma - mass spectrometry ICP - MS The laboratory results of the monitored participants will be prospectively recorded in the data collection form and in IBM SPSS
A literature review revealed very few publications on the effects of chromium serum levels on glucose metabolism lipid metabolism morbidity and mortality rates and the existing publications did not include samples of critically ill intensive care patients With this study the investigators aim to contribute to the national and international literature with a large sample of intensive care patients Thus the investigators goal is to provide a different perspective on solving the common problems of hyperglycemia and dyslipidemia encountered in intensive care patients aiming to reduce morbidity and mortality rates
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None