Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06339840
Status:
RECRUITING
Last Update Posted:
2024-07-01
First Post:
2024-03-14
Brief Title:
The Impact of Lifestyle Intervention on Weight and Fertility in Obese Males
Sponsor:
Third Affiliated Hospital of Zhengzhou University
Organization:
Third Affiliated Hospital of Zhengzhou University
Study Overview
Official Title:
The Impact of Lifestyle Intervention on Weight and Fertility in Obese Males
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obesity defined by WHO standards as having a body mass index BMI equal to or greater than 30 kgm² affects approximately 800 million people worldwide It is evident that obesity has become a serious public health issue resulting in significant health burdens
Previous systematic reviews have indicated an association between obesity and male factor infertility In populations undergoing assisted reproductive technology ART some studies have shown a correlation between increased male BMI and adverse ART outcomes Furthermore the negative effects of obesity may also be transmitted to offspring through genetic and epigenetic changes in reproductive cell DNA increasing their risk of obesity metabolic diseases or other chronic conditions
Currently there is a lack of data on the impact of weight loss in obese men on fertility and it is unclear which nutritional pattern in lifestyle interventions can more effectively control weight improve semen quality and address related endocrine issues in obese men thereby improving reproductive treatment outcomes
Based on previous literature we hypothesize that lifestyle interventions particularly strict low-carbohydrate diets combined with lifestyle guidance may offer greater health benefits for obese men These benefits include effective weight loss improvement in semen parameters reproductive metabolic health quality of life related to reproductive health and the impact on reproductive treatment outcomes This provides a basis for non-pharmacological intervention strategies and methods for the health of obese men
Previous systematic reviews have indicated an association between obesity and male factor infertility In populations undergoing assisted reproductive technology ART some studies have shown a correlation between increased male BMI and adverse ART outcomes Furthermore the negative effects of obesity may also be transmitted to offspring through genetic and epigenetic changes in reproductive cell DNA increasing their risk of obesity metabolic diseases or other chronic conditions
Currently there is a lack of data on the impact of weight loss in obese men on fertility and it is unclear which nutritional pattern in lifestyle interventions can more effectively control weight improve semen quality and address related endocrine issues in obese men thereby improving reproductive treatment outcomes
Based on previous literature we hypothesize that lifestyle interventions particularly strict low-carbohydrate diets combined with lifestyle guidance may offer greater health benefits for obese men These benefits include effective weight loss improvement in semen parameters reproductive metabolic health quality of life related to reproductive health and the impact on reproductive treatment outcomes This provides a basis for non-pharmacological intervention strategies and methods for the health of obese men
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None