Ignite Creation Date:
2024-05-06 @ 8:19 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06334588
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-03-28
First Post:
2024-02-22
Brief Title:
Understanding the Mechanisms of Autism an MRI and Social Cognition Study
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Understanding the Mechanisms of Autism an MRI and Social Cognition Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ECLAT
Brief Summary:
The main goal of this study is to investigate anatomo-functional brain abnormalities associated with autism spectrum disorders using a multimodal brain imaging approach as well as its links to social cognition difficulties measured using eye-tracking
Detailed Description:
Autism Spectrum Disorders ASD are neurodevelopmental disorders whose first manifestations appear early in childhood Even if ASDs present a wide heterogeneity in clinical manifestations abnormalities in social behavior characterized in particular by a lack of preference for social information remain the core of difficulties characteristic of autism
Brain imaging investigations have revealed anatomo-functional abnormalities in autism particularly in social brain regions In parallel eye-tracking studies have provided objective measures of social perception abnormalities in autism These results illustrate the relevance of these research strategies in the context of ASD Acquiring objective data on social behavior and linking them with brain imaging data opens up new avenues for research into the evolution of social skills during child development and the brain changes underlying this process
In this context the main hypothesis of this study is that the investigation of the neural bases of autism spectrum disorders using an approach combining multimodal brain imaging and the investigation of social behavior using eye-tracking would make it possible not only to better describe abnormalities but also to identify individual patterns at brain and behavioral level This could help to better characterize ASDs with and without genetic abnormalities an area which to date has received very little investigation In addition the objective measurements obtained with this approach would also enable the proposal of biomarkers which would contribute not only to better monitoring of the disorders evolution but also to the evaluation of the effectiveness of new therapeutic interventions
Brain imaging investigations have revealed anatomo-functional abnormalities in autism particularly in social brain regions In parallel eye-tracking studies have provided objective measures of social perception abnormalities in autism These results illustrate the relevance of these research strategies in the context of ASD Acquiring objective data on social behavior and linking them with brain imaging data opens up new avenues for research into the evolution of social skills during child development and the brain changes underlying this process
In this context the main hypothesis of this study is that the investigation of the neural bases of autism spectrum disorders using an approach combining multimodal brain imaging and the investigation of social behavior using eye-tracking would make it possible not only to better describe abnormalities but also to identify individual patterns at brain and behavioral level This could help to better characterize ASDs with and without genetic abnormalities an area which to date has received very little investigation In addition the objective measurements obtained with this approach would also enable the proposal of biomarkers which would contribute not only to better monitoring of the disorders evolution but also to the evaluation of the effectiveness of new therapeutic interventions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2023-A02668-37 | REGISTRY | ID-RCB | None |