Ignite Creation Date:
2024-05-06 @ 8:20 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06346990
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-05
First Post:
2024-03-29
Brief Title:
The Effect of Listening to Holy Quran Recital on the Incidence of Delirium Post-CABG
Sponsor:
Applied Science Private University
Organization:
Applied Science Private University
Study Overview
Official Title:
The Effect of Listening to Holy Quran Recital on the Incidence of Delirium Post-CABG A Randomized Control Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is planned to check the effect of holy Quran recital on the development of delirium after conronary artery bypass graft surgery CABG Different studies have been done before about the effects of non-pharmacological intervention on delirium after CABG howvere none was designed specifically to check the effect of Holy Qoyran on this outcome
Detailed Description:
Coronary artery disease is a very common cardiovascular disease nationwide Coronary artery bypass graft surgery CABG is a surgical treatment for coronary artery disease This surgery has positive outcomes for the patients compared to other revascularization procedures including lower levels of re-infarctions better quality of life extend patients lives and reduction of revascularization procedures Despite these benefits CABG is a major surgery that has its own risks and complications like bleeding wound infection extended use of mechanical ventilation cardiac dysthymias stroke pulmonary edema death and development of post-operative delirium The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition DSM-V describes delirium as a transient mental syndrome that is characterized by three main symptoms a Disturbance in attention ie reduced ability to direct focus sustain and shift attention and awareness reduced orientation to the environment b The disturbance develops over a short period of time usually hours to a few days represents an acute change from baseline attention and awareness and tends to fluctuate in severity during the course of a day c An additional disturbance in cognition eg memory deficit disorientation language visuospatial ability or perception There is also a need for evidence from physical exam and laboratory findings that these changes are not due to other conditions like drug abuse withdrawal symptoms or the use of medications9 Delirium is a common complication after CABG with high incidence rates ranging from 3 to 75 These high rates are linked to a number of negative outcomes including self-extubation respiratory failure sternal instability an extended hospital stay higher readmissions medical expenses and mortality rates and lower quality of life Even though delirium is common and has detrimental clinical effects medical professionals and staff frequently fail to recognize it According to earlier research between 32 and 84 of delirium cases go undetected by medical professionals Most of delirium cases occur after major and long surgeries like CABG not after minor surgeries These results indicate that the pathophysiology of postoperative delirium may be significantly influenced by anxiety stress and depressive responses brought on by surgical stimulation has been reported that stress anxiety and depression were high in the per-operative period and were associated negative outcomes as increased length of stay and occurrence delirium Primary prevention of delirium entails reducing effective risk factors such environmental interventions while secondary prevention involves early diagnosis Increasing or lowering environmental stimulation medicine and music therapy are some strategies to lower the frequency of delirium Fortunately delirium is a sickness that can be avoided Instead of treating this illness researchers have recently concentrated more on risk factor identification and prevention Therefore investigations involving medications like melatonin reduction of sedative medications as benzodiazepines and surgical methods were conducted with the aim of preventing these postoperative morbidities however the results have been inconclusive
Consequently non-pharmacological intervention to control delirium after CABG were studied like the use of music and education These non-pharmacological interventions work through the hypothesis that they will regulate the effect of anxiety stress and depression resulting in reducing heart rate blood pressure and pro-inflammatory cytokines In addition previous studies showed a connection between non-pharmacological interventions and reduction of postoperative pain and serum cortisol levels which in turn reduced the occurrence of delirium However none of these studies was designed specifically to check the effect of listing to Holy Quran on the incidence of delirium post CABG which might be working through the same mechanism Among patients how did CABG previous studies demonstrated that holy Quran audio therapy was significantly associated with reduction of anxiety and depressive symptoms136 Moreover listening to holy Quran recital significantly decreased pain and length of stay Also with regard to patients with heart problems other than CABG Quran audio therapy has been shown to reduce anxiety before cardiac catheterization procedures and enhance sleep quality following other cardiac surgeries Research questions 1 what is the incidence of delirium post CABG 2 what is the effect of listing to holy Quran on the incidence of delirium post CABG 3 what is the effect of listing to holy Quran on the length of stay post CABG and 4 what is the effect of delirium on the length of stay LoS post CABG
Consequently non-pharmacological intervention to control delirium after CABG were studied like the use of music and education These non-pharmacological interventions work through the hypothesis that they will regulate the effect of anxiety stress and depression resulting in reducing heart rate blood pressure and pro-inflammatory cytokines In addition previous studies showed a connection between non-pharmacological interventions and reduction of postoperative pain and serum cortisol levels which in turn reduced the occurrence of delirium However none of these studies was designed specifically to check the effect of listing to Holy Quran on the incidence of delirium post CABG which might be working through the same mechanism Among patients how did CABG previous studies demonstrated that holy Quran audio therapy was significantly associated with reduction of anxiety and depressive symptoms136 Moreover listening to holy Quran recital significantly decreased pain and length of stay Also with regard to patients with heart problems other than CABG Quran audio therapy has been shown to reduce anxiety before cardiac catheterization procedures and enhance sleep quality following other cardiac surgeries Research questions 1 what is the incidence of delirium post CABG 2 what is the effect of listing to holy Quran on the incidence of delirium post CABG 3 what is the effect of listing to holy Quran on the length of stay post CABG and 4 what is the effect of delirium on the length of stay LoS post CABG
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None