Ignite Creation Date:
2024-05-06 @ 8:20 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06342128
Status:
RECRUITING
Last Update Posted:
2024-04-03
First Post:
2024-03-26
Brief Title:
Molecular Landscape of Microvascular Inflammation in Kidney Allografts
Sponsor:
Paris Translational Research Center for Organ Transplantation
Organization:
Paris Translational Research Center for Organ Transplantation
Study Overview
Official Title:
Comprehensive Multiscale Characterization of the Molecular Landscape of Microvascular Inflammation in Kidney Allografts
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Microvascular inflammation in kidney allografts has been widely reappraised in the recent update of Banff classification There is a critical need to better understand the pathophysiological mechanisms associated with the various phenotypes of microvascular inflammation that are observed in kidney transplants particularly in order to develop targeted therapeutic approaches
Detailed Description:
Antibody-mediated rejection is a major cause of graft failure in kidney transplant recipients The diagnostic criteria for antibody-mediated rejection have undergone significant changes since their initial definition in the international Banff Classification system The Banff 2022 Classification update reappraises lesions of microvascular inflammation and identifies new phenotypes for cases with microvascular inflammation However pathophysiological mechanisms associated with microvascular inflammation in kidney allografts are still poorly understood thus hampering the development of efficient treatments
The aims of this study are
1 To decipher the spatial immune-molecular landscape of microvascular inflammation in kidney allografts
2 To compare the characteristics of this landscape in different clinical scenarios
The investigators will use a multimodal phenotyping approach including histological analyses and multiplex immunostainings bulk transcriptomic analyses and spatial whole-transcriptome digital profiling to decipher the molecular landscape of microvascular inflammation in kidney allografts Based on these results they will investigate its association with allograft outcomes and search for molecular targets which could benefit from targeted therapeutic strategies
The aims of this study are
1 To decipher the spatial immune-molecular landscape of microvascular inflammation in kidney allografts
2 To compare the characteristics of this landscape in different clinical scenarios
The investigators will use a multimodal phenotyping approach including histological analyses and multiplex immunostainings bulk transcriptomic analyses and spatial whole-transcriptome digital profiling to decipher the molecular landscape of microvascular inflammation in kidney allografts Based on these results they will investigate its association with allograft outcomes and search for molecular targets which could benefit from targeted therapeutic strategies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None