Ignite Creation Date:
2024-05-06 @ 8:21 PM
Last Modification Date:
2024-10-26 @ 3:25 PM
Study NCT ID:
NCT06342661
Status:
RECRUITING
Last Update Posted:
2024-04-02
First Post:
2024-03-26
Brief Title:
Study On the Expression Level and Clinical Significance of VISTA in Patients With Vascular Cognitive Impairment
Sponsor:
First Affiliated Hospital of Harbin Medical University
Organization:
First Affiliated Hospital of Harbin Medical University
Study Overview
Official Title:
Study On the Expression Level and Clinical Significance of VISTA in Patients With Vascular Cognitive Impairment
Status:
RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Explore the expression level of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid of patients with cardiovascular risk factors 2 Discuss the correlation between different risk factors mainly hypertension diabetes smoking hyperlipidemia hyperhomocysteinemia etc and the expression level of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid of patients with cerebrovascular diseases and immune-inflammatory related diseases of the nervous system 3 Explore the correlation between different immune inflammatory factors IL1 IL6 IL10 INFγ TNFα and the expression level of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid of patients 4 Track and explore the dynamic changes of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid of patients with cardiovascular risk factors in 3 months 1 year 3 years and 5 years
Detailed Description:
The prospective observational study design was adopted to screen patients with cardiovascular risk factors who visited the Department of Neurology in the First Hospital of Harbin Medical University since November 2022 The patients mainly categorize into two groups without cognitive impairment control and with cognitive impairment VCI General information imaging functional assessment immune checkpoint VISTA in peripheral blood and cerebrospinal fluid and blood-related indicators were collected Some patients who could cooperate were followed up for 3-5 years By analyzing the correlation between the content of immune checkpoint VISTA in peripheral blood and cerebrospinal fluid disease risk factors imaging functional scores and blood indicators the relationship between immune checkpoints and nervous system diseases was better understood
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None