Ignite Creation Date:
2024-05-06 @ 8:21 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06359795
Status:
RECRUITING
Last Update Posted:
2024-04-11
First Post:
2024-04-07
Brief Title:
Exploring the Value of 18F-AlF-FAPI PETCT in Assessing the Activity of Thyroid Eye Disease
Sponsor:
Peking University Third Hospital
Organization:
Peking University Third Hospital
Study Overview
Official Title:
Exploring the Value of 18F-AlF-FAPI PETCT in Assessing the Activity of Thyroid Eye Disease
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
FAPI PET has been developed as a promising approach for the evaluation of fibroinflammatory such as in inflammatory bowel disease This prospective study aims to explore the value of 18F-AlF-FAPI PETCT in assessing the activity of Thyroid Eye Disease TED and investigate whether FAPI PETCT may be superior to 99mTc-DTPA SPECTCT for the diagnosis therapy response assessment and follow-up of TED
Detailed Description:
Subjects with TED underwent 18F-AlF-FAPI PETCT and 99mTc-DTPA SPECTCT for activity assessment within a 10-day period On 18F-AlF-FAPI PETCT uptake in the extraocular muscles was quantified using SUV metrics and target-to-background ratio On 99mTc-DTPA SPECTCT uptake in the extraocular muscles was semi-quantified using the uptake ratio Activity of TED was determined through comprehensive clinical data The correlation between SUV metrics and activity status was calculated to explore the value of 18F-AlF-FAPI PETCT in assessing TED activity The diagnostic accuracy of 18F-AlF-FAPI PETCT and 99mTc-DTPA SPECTCT in assessing TED activity was compared Additionally the correlation of changes in SUV metrics and therapy response will be calculated to explore the value of 18F-AlF-FAPI PETCT in therapy response assessment of TED
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None