Ignite Creation Date:
2024-05-06 @ 8:21 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06359444
Status:
RECRUITING
Last Update Posted:
2024-06-07
First Post:
2024-02-01
Brief Title:
Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD
Sponsor:
University Ghent
Organization:
University Hospital Ghent
Study Overview
Official Title:
Effect of High Intensity Exercise Rehabilitation on Hepatic Fatty Acids Liver Function Insulin Sensitivity and Cardiovascular Risk in Patients With MASLD
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CENSORIAL
Brief Summary:
Metabolic dysfunction-associated steatotic liver disease MASLD is the most common liver disease worldwide and is associated with obesity and the metabolic syndrome Physical activity and lifestyle interventions are among the most recommended treatments for individuals with MASLD
In this RCT we will evaluate the effect of combined exercise training strength and aerobic training versus strength and high intensity training HIIT The main outcome parameter is the severity of liver steatosis Patients will be recruited at the fatty liver clinic of the UZ Gent
In this RCT we will evaluate the effect of combined exercise training strength and aerobic training versus strength and high intensity training HIIT The main outcome parameter is the severity of liver steatosis Patients will be recruited at the fatty liver clinic of the UZ Gent
Detailed Description:
Physical activity and lifestyle interventions including exercise are recommended for individuals with metabolic dysfunction-associated steatotic liver disease MASLD Weight loss has been found to improve MASLD histologically but exercise alone can also reduce liver fat accumulation even without significant weight loss Exercise has positive effects on chronic inflammation type 2 diabetes mellitus T2DM and mitochondrial function in MASLD patients Studies suggest that both aerobic and resistance exercise are effective in reducing fat content and liver enzyme levels in MASLD and thereby generate positive effects on insulin sensitivity and cardiovascular risk The potential of high-intensity interval training HIIT is large in various settings but was never explored in this population Moreover the combination with strength training can have additional health effects which remain to be explored
All subjects are recruited in the liver steatosis outpatient clinic of the university hospital in Ghent by the physicians and researchers of this study After patient selection and obtaining informed consent they will be screened in the rehabilitation center for cardiorespiratory fitness
All subjects are recruited in the liver steatosis outpatient clinic of the university hospital in Ghent by the physicians and researchers of this study After patient selection and obtaining informed consent they will be screened in the rehabilitation center for cardiorespiratory fitness
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None