Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06357104
Status:
COMPLETED
Last Update Posted:
2024-04-10
First Post:
2024-03-10
Brief Title:
Detoxification From the Lipid Tract
Sponsor:
Pachankis Yang I MD
Organization:
Pachankis Yang I MD
Study Overview
Official Title:
Detoxification From the Lipid Tract by Cocktail Design
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Apart from electroencephalogram biofeedback and electrical brain stimulation adopted for maintenance treatment the study utilizes ultra-low frequency transcranial magnetic stimulation ULF-TMS for initial γ-aminobutyric acid GABA stimulation The cocktail therapy starts after the primary efficacy endpoint and concomitant therapy is adopted throughout the study
Detailed Description:
It was tested that GABA in the joint action with topiramate modulates macrophage activities by modulating cholesterol-metabolism associated molecules GABA A receptors exhibit highly dynamic trafficking and cell surface mobility and influence on post-endocytic effects Benzodiazepines BZDs exercise the mechanism of action by facilitating the binding of the inhibitory neurotransmitter GABA at various GABA receptors throughout the central nervous system CNS Alprazolam a type of BZD was tested by Al-Tubuly Aburawi Alghzewi Gorash and Errwami in joint action with water-soluble beta blocker atenolol in comparison with the non-selective β-adrenoceptor antagonist propranolol on the pharmacological effects on depression The study hypothesizes that by replacing the water-soluble beta blocker to lipid-soluble one metoprolol the effect of detoxification from the lipid and sebaceous immunobiological pathways can be achieved by the clathrin-dependent endocytosis process
Even though partial progress was made in the NCT05839236 trial by statin therapies the therapeutic effects have not been lasting nor significant The study develops from the previous protocol for a cocktail therapy by the joint mechanism of actions of alprazolam metoprolol and pravastatin sodium for the detoxification process
Even though partial progress was made in the NCT05839236 trial by statin therapies the therapeutic effects have not been lasting nor significant The study develops from the previous protocol for a cocktail therapy by the joint mechanism of actions of alprazolam metoprolol and pravastatin sodium for the detoxification process
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None