Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06352515
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-29
First Post:
2024-04-02
Brief Title:
T Lymphocyte Subsets in Ulcerative Colitis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Peripheral Blood T Lymphocyte Subsets in Ulcerative Colitis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Study the distribution of peripheral blood T lymphocyte subsets among ulcerative colitis patients
2 Correlation of T-cell subsets to therapeutic response disease activity
3 Assess the value of circulating IgG anti-Integrin αvβ6 in UC
2 Correlation of T-cell subsets to therapeutic response disease activity
3 Assess the value of circulating IgG anti-Integrin αvβ6 in UC
Detailed Description:
Ulcerative colitis UC is an idiopathic chronic inflammatory disease of the large intestine frequently involving the rectum and characterized by chronic and recurrent mucosal inflammation and ulceration Although its cause is not well understood current evidence suggests innate and adaptive immunity play critical roles in its pathogenesis
One of the main classes of immune cells that are affected by and contribute to UC is T cells T-lymphocytes comprise a complex collection of highly differentiated T-cell subsets playing key roles in the regulation and the effector phase of the immune response CD4 T cells were found over-activated and proliferated in UC patients which can induce disorders of the cytokine network and increase the occurrence of colitis
Once intestinal pathogens or inflammatory mediators are not cleared in time pro-inflammatory mononuclear phagocytes MNPs or polymorphonuclear leukocytes PMNs are often recruited to promote the polarization of naive CD4 T cells into Th1 Th2 Th17 Treg and other subsets of cells
The balances Th17 Treg cells are important for maintaining intestinal homeostasis Once the proportion Th17 cells increases it often induces the production of pro-inflammatory cytokines that promote colonic inflammation whereas Treg cells are usually secrete interleukin-10 IL-10 and transforming growth factor-β TGF-β for anti-inflammatory regulations
UC-associated inflammation is also characterized by huge number of activated B cells and plasma cells the latter being involved in the production of cytotoxic granules immunoglobulins and various autoantibodies Recent studies have highlighted a novel autoantibody against integrin αvβ6 in the serum of patients diagnosed with UC
Recently targeting immune cells to inhibit inflammation has become a research hotspot Biological therapies are highly effective hallmark therapies in UC Despite their widespread use the impact of these agents on the composition of the adaptive immune system is largely unexplored Knowledge on such effects in UC could clarify the mechanism of action of these therapies provide information about the status of the adaptive immune system and could help finding cell-based markers
One of the main classes of immune cells that are affected by and contribute to UC is T cells T-lymphocytes comprise a complex collection of highly differentiated T-cell subsets playing key roles in the regulation and the effector phase of the immune response CD4 T cells were found over-activated and proliferated in UC patients which can induce disorders of the cytokine network and increase the occurrence of colitis
Once intestinal pathogens or inflammatory mediators are not cleared in time pro-inflammatory mononuclear phagocytes MNPs or polymorphonuclear leukocytes PMNs are often recruited to promote the polarization of naive CD4 T cells into Th1 Th2 Th17 Treg and other subsets of cells
The balances Th17 Treg cells are important for maintaining intestinal homeostasis Once the proportion Th17 cells increases it often induces the production of pro-inflammatory cytokines that promote colonic inflammation whereas Treg cells are usually secrete interleukin-10 IL-10 and transforming growth factor-β TGF-β for anti-inflammatory regulations
UC-associated inflammation is also characterized by huge number of activated B cells and plasma cells the latter being involved in the production of cytotoxic granules immunoglobulins and various autoantibodies Recent studies have highlighted a novel autoantibody against integrin αvβ6 in the serum of patients diagnosed with UC
Recently targeting immune cells to inhibit inflammation has become a research hotspot Biological therapies are highly effective hallmark therapies in UC Despite their widespread use the impact of these agents on the composition of the adaptive immune system is largely unexplored Knowledge on such effects in UC could clarify the mechanism of action of these therapies provide information about the status of the adaptive immune system and could help finding cell-based markers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None