Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06354842
Status:
COMPLETED
Last Update Posted:
2024-04-09
First Post:
2024-04-03
Brief Title:
Measurement of Sweat Sodium Concentration in Patients With Chronic Kidney Disease
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Application of Pilocarpine Iontophoresis in Patients With Chronic Kidney Disease a Feasibility Study
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It has been shown that excretion of sodium and water through the skin in the form of sweat represents a regulatory mechanism of electrolyte- and fluid balance Since patients with chronic kidney disease CKD exhibit increased skin sodium content we investigated the feasibility of sweat testing as a novel experimental tool to a more complete assessment of fluid- and sodium homeostasis
In this cross-sectional feasibility study we applied pilocarpine iontophoresis to induce sweat testing in 58 patients across various stages of CKD including patients after kidney transplantation as well as a healthy control cohort n6 to investigate possible effects of CKD and transplantation status on sweat rate and sodium concentration Due to non-linear relationships we modeled our data using polynomial regression
Decline of kidney function showed a significant association with lower sweat rates adj R² 02278 F2 61 1029 p 0000141 Sweat sodium concentrations were increased in moderate CKD however this effect was lost in end stage renal disease adj R² 03701 F4 59 1026 p 2261e-06 We observed higher sweat weight in males compared to females
Diagnostic sweat analysis represents an innovative and promising noninvasive option for more thorough investigation of sodium- and fluid homeostasis in CKD patients Lower sweat rates and higher sweat sodium concentrations represent a unique feature of CKD patients with potential therapeutic implications
In this cross-sectional feasibility study we applied pilocarpine iontophoresis to induce sweat testing in 58 patients across various stages of CKD including patients after kidney transplantation as well as a healthy control cohort n6 to investigate possible effects of CKD and transplantation status on sweat rate and sodium concentration Due to non-linear relationships we modeled our data using polynomial regression
Decline of kidney function showed a significant association with lower sweat rates adj R² 02278 F2 61 1029 p 0000141 Sweat sodium concentrations were increased in moderate CKD however this effect was lost in end stage renal disease adj R² 03701 F4 59 1026 p 2261e-06 We observed higher sweat weight in males compared to females
Diagnostic sweat analysis represents an innovative and promising noninvasive option for more thorough investigation of sodium- and fluid homeostasis in CKD patients Lower sweat rates and higher sweat sodium concentrations represent a unique feature of CKD patients with potential therapeutic implications
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None