Ignite Creation Date:
2024-05-06 @ 8:22 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06359483
Status:
COMPLETED
Last Update Posted:
2024-04-11
First Post:
2024-03-31
Brief Title:
The Impact of Meal Frequency on Bone Remodeling in Healthy Adults
Sponsor:
University of Jordan
Organization:
University of Jordan
Study Overview
Official Title:
A Randomized Controlled Pilot Study on the Short-Term Impact of Meal Frequency on Bone Remodeling in Healthy Adults
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aimed to investigate the effect of meal frequency on bone remodeling using the marker Procollagen Type 1 N-terminal propeptide P1NP Thirty healthy adult males from Jordan participated in a randomized controlled intervention trial They were randomly assigned to three or eight daily meals for three consecutive days over two phases Blood samples were obtained at the beginning and end of each phase and P1NP levels were analyzed The results showed a substantial drop in P1NP levels compared to the baseline indicating that meal frequency influences bone development There were no significant changes between the groups eating three and eight meals per day The study emphasizes the importance of dietary patterns in bone health and advises additional research to understand the relationship between meal frequency and bone metabolism
Detailed Description:
The study looked into how meal frequency influences bone remodeling focusing on the Procollagen Type 1 N-terminal propeptide P1NP marker which indicates bone production Bone remodeling is a continual process in which osteoclasts break down bone tissue and osteoblasts form new bone tissue Dietary patterns are increasingly recognized as influencing bone remodeling and general bone health with meal frequency playing an important role in bone metabolism
To perform the study 30 healthy adult males aged 19 to 30 were recruited from Jordan using informational flyers They participated in a randomized controlled intervention experiment The participants were randomly allocated to one of two groups one group ate three meals per day and the other ate eight meals per day This dietary pattern was followed for three consecutive days in what was referred to as Phase 1 of the study
Following Phase 1 there was a one-week washout phase to remove any residual effects from the previous food pattern Following the washout period the participants were moved to an alternate meal frequency ie those who had three meals per day were now eating eight and vice versa for another three days known as Phase 2
Blood samples were collected from participants at baseline before beginning the food intervention and after each phase of the trial The levels of P1NP in the blood samples were determined using an enzyme-linked immunosorbent assay ELISA a widely used laboratory technique for detecting and quantifying chemicals
To perform the study 30 healthy adult males aged 19 to 30 were recruited from Jordan using informational flyers They participated in a randomized controlled intervention experiment The participants were randomly allocated to one of two groups one group ate three meals per day and the other ate eight meals per day This dietary pattern was followed for three consecutive days in what was referred to as Phase 1 of the study
Following Phase 1 there was a one-week washout phase to remove any residual effects from the previous food pattern Following the washout period the participants were moved to an alternate meal frequency ie those who had three meals per day were now eating eight and vice versa for another three days known as Phase 2
Blood samples were collected from participants at baseline before beginning the food intervention and after each phase of the trial The levels of P1NP in the blood samples were determined using an enzyme-linked immunosorbent assay ELISA a widely used laboratory technique for detecting and quantifying chemicals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None