Ignite Creation Date:
2024-05-06 @ 8:23 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06365385
Status:
RECRUITING
Last Update Posted:
2024-05-16
First Post:
2024-04-09
Brief Title:
Postprandial Metabolic and Appetite Responses to Different Food Intake Sequences in Athletes
Sponsor:
Universidade do Porto
Organization:
Universidade do Porto
Study Overview
Official Title:
Postprandial Metabolic and Appetite Responses to Different Food Intake Sequences in Athletes
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Emerging evidence suggests that following a carbohydrate-last meal pattern wherein foods rich in protein fat fiber andor polyphenols are consumed before sources of simple carbohydrate CHO in a meal results in reduced postprandial glycaemic responses than the reverse food order or a co-ingestion pattern This effect has been observed across the spectrum of glucose tolerance from patients with diabetes to individuals with normal glucose tolerance Kuwata et al 2016 Nishino et al 2018 Lu et al 2019 Sun et al 2020 Furthermore reduced glucose excursions have been linked to decreased subsequent hunger and energy intake Lu et al 2019 Wyatt et al 2021
However to date no studies on food intake sequence have targeted athletes despite their increased CHO demands Thomas et al 2016 which could expose them to repeated episodes of hyperglycaemia and high glycaemic variability known to increase the risk of adverse cardiovascular outcomes and all-cause mortality Loader et al 2015 Cavero-Redondo et al 2017 Faerch et al 2018 Additionally athletes often face pressure to meet body composition standards and may benefit from strategies that enhance satiety and craving control Finally there is reason to believe that better glycaemic control could lead to improved performance given that enhancements in endurance activities have been observed with a low-glycemic-index diet compared to a high-glycemic-index diet Heung-Sang Wong et al 2017
Therefore this randomised crossover trial is part of a wider project which seeks to explore the impact of food intake sequence on metabolic health and performance in athletes Specifically this trial aims to investigate the acute postprandial metabolic and appetite responses to consuming an identical meal in two intake sequences CHO-last versus CHO-first in athletes while in the resting state
However to date no studies on food intake sequence have targeted athletes despite their increased CHO demands Thomas et al 2016 which could expose them to repeated episodes of hyperglycaemia and high glycaemic variability known to increase the risk of adverse cardiovascular outcomes and all-cause mortality Loader et al 2015 Cavero-Redondo et al 2017 Faerch et al 2018 Additionally athletes often face pressure to meet body composition standards and may benefit from strategies that enhance satiety and craving control Finally there is reason to believe that better glycaemic control could lead to improved performance given that enhancements in endurance activities have been observed with a low-glycemic-index diet compared to a high-glycemic-index diet Heung-Sang Wong et al 2017
Therefore this randomised crossover trial is part of a wider project which seeks to explore the impact of food intake sequence on metabolic health and performance in athletes Specifically this trial aims to investigate the acute postprandial metabolic and appetite responses to consuming an identical meal in two intake sequences CHO-last versus CHO-first in athletes while in the resting state
Detailed Description:
Participants will be required to visit the research facilities at Cidade do Futebol Portugal Football Schools headquarters on three separate occasions following a 10-12-hour overnight fast and abstaining from alcohol consumption and strenuous physical activity the day before eg no exercise causing sweating or heavy breathing Visits will be separated by a wash-out period of 7 days to ensure participants experience similar dietary and physical activity patterns in the 24 hours preceding the trials Each visit is expected to last approximately 4 hours
In the screening and familiarisation visit athletes will be asked to provide written informed consent to participate in the study and answer a series of questions to confirm their eligibility and safety for enrolment Subsequently an anthropometric assessment blood pressure measurement fasted blood collection and 2-hour 75-g oral glucose tolerance test OGTT will be performed to establish participants baseline characteristics and analyse biochemical markers of the glucose and lipid metabolism to identify any further exclusion criteria ie glycated haemoglobin HbA1c glucose insulin triglycerides total high-density lipoprotein and low-density lipoprotein cholesterol haemogram and high-sensitivity C-reactive protein To familiarise participants with the cannulation procedure ahead of the experimental trials a trained and experienced nurse will insert a cannula a small plastic tube into a vein on the participants arm from which fasting and 2-h OGTT blood samples will be drawn 15 ml in total
Eligible participants will be instructed to monitor their diet and physical activity for 24 hours before their first experimental visit and replicate these patterns before the second experimental visit
In both experimental visits participants will arrive at the research facilities between 800-900 and rest comfortably for 10 minutes Body mass and blood pressure will be remeasured Then cannulation will be performed and 185 ml venous blood samples will be drawn immediately before and at 30 60 90 120 and 180 minutes after the meal challenge to assess postprandial changes in insulin glucagon-like peptide-1 GLP-1 glucose-dependent insulinotropic polypeptide GIP ghrelin peptide YY PYY triglycerides and non-esterified fatty acids NEFA concentrations At similar timepoints as well as at 15 and 45 minutes capillary blood glucose will be measured using a finger prick glucometer and appetite ratings will be marked by the athletes on 100-mm visual analogue scales
Upon completing the research assessments participants will be asked to photograph and record the timing type and amounts of foods drinks andor supplements consumed for an additional 3 hours to evaluate their prospective ad libitum intake
In the screening and familiarisation visit athletes will be asked to provide written informed consent to participate in the study and answer a series of questions to confirm their eligibility and safety for enrolment Subsequently an anthropometric assessment blood pressure measurement fasted blood collection and 2-hour 75-g oral glucose tolerance test OGTT will be performed to establish participants baseline characteristics and analyse biochemical markers of the glucose and lipid metabolism to identify any further exclusion criteria ie glycated haemoglobin HbA1c glucose insulin triglycerides total high-density lipoprotein and low-density lipoprotein cholesterol haemogram and high-sensitivity C-reactive protein To familiarise participants with the cannulation procedure ahead of the experimental trials a trained and experienced nurse will insert a cannula a small plastic tube into a vein on the participants arm from which fasting and 2-h OGTT blood samples will be drawn 15 ml in total
Eligible participants will be instructed to monitor their diet and physical activity for 24 hours before their first experimental visit and replicate these patterns before the second experimental visit
In both experimental visits participants will arrive at the research facilities between 800-900 and rest comfortably for 10 minutes Body mass and blood pressure will be remeasured Then cannulation will be performed and 185 ml venous blood samples will be drawn immediately before and at 30 60 90 120 and 180 minutes after the meal challenge to assess postprandial changes in insulin glucagon-like peptide-1 GLP-1 glucose-dependent insulinotropic polypeptide GIP ghrelin peptide YY PYY triglycerides and non-esterified fatty acids NEFA concentrations At similar timepoints as well as at 15 and 45 minutes capillary blood glucose will be measured using a finger prick glucometer and appetite ratings will be marked by the athletes on 100-mm visual analogue scales
Upon completing the research assessments participants will be asked to photograph and record the timing type and amounts of foods drinks andor supplements consumed for an additional 3 hours to evaluate their prospective ad libitum intake
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None