Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06363253
Status:
RECRUITING
Last Update Posted:
2024-04-12
First Post:
2024-04-09
Brief Title:
Pilot Study of the Human Metagenome in Metabolic Diseases
Sponsor:
Sengkang General Hospital
Organization:
Sengkang General Hospital
Study Overview
Official Title:
Understanding the Role of the Human Metagenome in Obesity Metabolic Diseases Chronic Inflammation Sarcopenia and Sarcopenic Obesity - a Pilot Study
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a cohort study to understand the role of the human metagenome and associated metabolites in health and in various diseased states in particular obesity as well as sarcopenia
Recruited participants will have their fecal salivary urine serum and in certain instances mucosal samples taken for metagenomic sequencing and metabolite testing
We hope to uncover various differences and signatures in the metagenome and metabolome in various diseased states with potential future therapeutic applications in personalised medicine
Recruited participants will have their fecal salivary urine serum and in certain instances mucosal samples taken for metagenomic sequencing and metabolite testing
We hope to uncover various differences and signatures in the metagenome and metabolome in various diseased states with potential future therapeutic applications in personalised medicine
Detailed Description:
The human metagenome comprises all nucleotide sequences isolated from all organisms living on and within an individual and has been shown to have significant alterations in relation to certain diseased states related to chronic inflammation such as obesity and sarcopenia
The gut bacteriome and more recently the virome has been shown to be significantly correlated with the obese phenotype while gut microbiome dysbiosis is known to occur in individuals with sarcopenia Clinically there is an unmet clinical need to better personalize the treatment of patients with metabolic disorders such as obesity and metabolic syndrome and patients suffering from sarcopenia and frailty as a result of aging However the literature regarding the metagenomic signatures associated with these disorders in particular the non-bacteriome species bacterial metabolites and their relationship with host metabolism were scarce
Thus we hypothesize that the human metagenome and metabolome may play a role in influencing chronic inflammatory disorders related to metabolic disorders such as obesity and diseases related to aging like sarcopenia and aging
This is a cohort study involving metagenomic sequencing and metabolomic analysis of patients metagenome and metabolome in various diseased states A cohort of healthy control patients without obesity or sarcopenia will also be recruited
Samples collected will include fecal salivary serum urine mucosal samples for metagenomic sequencing and metabolomic testing
The gut bacteriome and more recently the virome has been shown to be significantly correlated with the obese phenotype while gut microbiome dysbiosis is known to occur in individuals with sarcopenia Clinically there is an unmet clinical need to better personalize the treatment of patients with metabolic disorders such as obesity and metabolic syndrome and patients suffering from sarcopenia and frailty as a result of aging However the literature regarding the metagenomic signatures associated with these disorders in particular the non-bacteriome species bacterial metabolites and their relationship with host metabolism were scarce
Thus we hypothesize that the human metagenome and metabolome may play a role in influencing chronic inflammatory disorders related to metabolic disorders such as obesity and diseases related to aging like sarcopenia and aging
This is a cohort study involving metagenomic sequencing and metabolomic analysis of patients metagenome and metabolome in various diseased states A cohort of healthy control patients without obesity or sarcopenia will also be recruited
Samples collected will include fecal salivary serum urine mucosal samples for metagenomic sequencing and metabolomic testing
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None