Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06360185
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-11
First Post:
2023-12-15
Brief Title:
Retrospective Study of Patients With Acute Presentation for Asthma to an Emergency Department in UK RAPAE
Sponsor:
Norfolk and Norwich University Hospitals NHS Foundation Trust
Organization:
Norfolk and Norwich University Hospitals NHS Foundation Trust
Study Overview
Official Title:
Retrospective Study Investigating the Clinical Characteristic of Patients With Acute Presentation for Asthma to the AE Department in a Busy Acute Hospital in England UK in Era of Biological Therapy for Asthma Between January 2019 and January 2024
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RAPAE
Brief Summary:
Study team will obtain a list of all patients who have been seen in AE over the past 6 years with a discharge diagnosis of asthma Their history will be reviewed from their AE notes Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participants GP records Team will use participants postcode to word out socio economic status quintile using office of national statistics tool The following information will be taken from hospital documentation and from GP records
Detailed Description:
1 How many previous admissions in past one year 12 months
2 How many presentations to AE in previous one year 12 months
3 Diagnosis not confirmed therefore not on any ICS
4 Poor compliance less than 75 of ICS andor LABA andor LAMA andor leukotriene prescriptions picked up in past year
5 Recent presentation and maintenance therapy not increased primary care or secondary care issue
6 Is patient overweight BMI
7 Is patient on hormonal therapy OCP HRT male hormones
8 Social class quintile from post code of address using ONS calculator
9 Ethnically diverse see appendix
10 First Eosinophil count on index admission
11 Highest eosinophil count in past ever and date
12 Treatment for diabetes type 2
13 Treatment for diabetes type 1
14 Treatment for hypertension
15 Smoker ever pack year when gave up__________
After obtaining this information study team will use simple statistical methods such as frequency and associations with confidence intervals to investigate which factors are associated with frequency of presentation to AE They will ascertain the frequency of patients who are on maximum therapy and may benefit from biological therapy especially if they have raised eosinophils in the past year
2 How many presentations to AE in previous one year 12 months
3 Diagnosis not confirmed therefore not on any ICS
4 Poor compliance less than 75 of ICS andor LABA andor LAMA andor leukotriene prescriptions picked up in past year
5 Recent presentation and maintenance therapy not increased primary care or secondary care issue
6 Is patient overweight BMI
7 Is patient on hormonal therapy OCP HRT male hormones
8 Social class quintile from post code of address using ONS calculator
9 Ethnically diverse see appendix
10 First Eosinophil count on index admission
11 Highest eosinophil count in past ever and date
12 Treatment for diabetes type 2
13 Treatment for diabetes type 1
14 Treatment for hypertension
15 Smoker ever pack year when gave up__________
After obtaining this information study team will use simple statistical methods such as frequency and associations with confidence intervals to investigate which factors are associated with frequency of presentation to AE They will ascertain the frequency of patients who are on maximum therapy and may benefit from biological therapy especially if they have raised eosinophils in the past year
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None