Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06362330
Status:
RECRUITING
Last Update Posted:
2024-04-12
First Post:
2024-04-06
Brief Title:
Multi-parametric MRI in Patients of Bladder Cancer
Sponsor:
The First Affiliated Hospital with Nanjing Medical University
Organization:
The First Affiliated Hospital with Nanjing Medical University
Study Overview
Official Title:
Knowledge-guided Causal Diagnostic Network for the Detection of Muscle-invasive Bladder Cancer With Single T2-weighted Imaging
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Accurate preoperative detection of muscle-invasive bladder cancer remains a clinical challenge The investigators aimed to develop and validate a knowledge-guided causal diagnostic network for the detection of muscle-invasive bladder cancer with multiparametric magnetic resonance imagingMRI
Detailed Description:
Patients who underwent bladder MRI were retrospectively collected at three centers between January 2013 and September 2023 The investigators first constructed a nnUNet to segment causal region where muscle-invasive bladder cancer may occur Subsequently the investigators explored a causal network based on a modified ResNet3d-18 by striking a fine balance between nnUNet awareness and a self-supervised learning SSL model which steered model to emulate diagnostic acumen of expert in staging muscle-invasive bladder cancer at MRI Model was trained in center 1 and independently tested in center 1 center 2 and center 3 Ablation test was performed among all 13 Ablation-Test models using either single or multi-parametric MRI Benefit was tested in six radiologists using vesical imaging-reporting and data system VI-RADS versus network-adjusted VI-RADS
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None