Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:26 PM
Study NCT ID:
NCT06363058
Status:
RECRUITING
Last Update Posted:
2024-04-17
First Post:
2024-03-28
Brief Title:
Electrical Stimulation Cycling Training Effects on SCA
Sponsor:
Chang Gung University
Organization:
Chang Gung University
Study Overview
Official Title:
Effect of Combined ES Cycling Training on Individuals With SCA
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To focuses on the challenges faced by individuals with spinocerebellar ataxia SCA highlighting the major clinical sign of ataxia that affects their stability and ability to perform daily activities thereby impacting their quality of life It outlines the concept of neural plasticity which is the brains ability to adapt through changes in excitability and notes that these changes are more enduring in the central nervous system CNS than in the peripheral nervous system PNS This adaptability crucial for memory and motor learning is compromised in SCA patients due to impaired brain areas and pathways The summary further delves into motor learning distinguishing between explicit and implicit learning and points out that SCA patients exhibit deficiencies in procedural learning and cerebellar function It also introduces the concept of priming as a preparatory mechanism that can enhance the effectiveness of physical therapy by modifying subsequent responses to stimuli The document suggests that cycling as an aerobic exercise could prime the brain for improved blood flow and oxygenation thereby supporting synaptic plasticity and the release of beneficial neurotrophic factors Finally the project aims to deepen the understanding of motor performance and learning mechanisms in SCA patients and apply these insights to clinical rehabilitation strategies
Detailed Description:
Ataxia is the major clinical sign of spinocerebellar ataxia SCA patients Increased postural sway and instability during volitional movements appear and hinder SCA patients from performing normal daily life activities and influence quality of life of victims
Neural plasticity comes from excitability changes Changes in excitability produced by repetitive activities at synapses maintain a longer time in the central nervous system CNS than the changes in the peripheral nervous system PNS The long duration of synaptic excitability changes may be linked to memory and motor learning Neural plasticity could be investigated by several non-invasive instruments such as Transcranial Magnetic Stimulation TMS The excitability is suppressed in SCA patients due to corrupted brain areas and pathways
Motor learning is the process of obtaining the capability for movement Motor learning is not merely focusing on changes in performance during practice but also being evaluated during retention andor transfer Motor learning can be divided into explicit and implicit learning One type of implicit learning is the acquisition of motor skills often referred to as procedural learning Serial reaction time task SRTT is used to describe implicit sequence motor learning A series of implicit motor sequence learning tasks is to clarify the role and function of the cerebellum And this function is deficient in SCA patients
Priming is an unconscious process associated with learning to alter the later response by the proceeding stimulus Priming is applied to physical therapy it could result in behavioral change and strengthen the training effect afterward
Cycling could be an aerobic exercise priming that may help to raise brain blood flow and oxygenation facilitate synaptic plasticity augment the release of neurotrophic factors to transmit neuroendocrine and myokines
This project will advance the knowledge of the mechanism of motor performance and motor learning in SCA individuals The result of this project can be applied to the clinical rehabilitation of people with SCA
Neural plasticity comes from excitability changes Changes in excitability produced by repetitive activities at synapses maintain a longer time in the central nervous system CNS than the changes in the peripheral nervous system PNS The long duration of synaptic excitability changes may be linked to memory and motor learning Neural plasticity could be investigated by several non-invasive instruments such as Transcranial Magnetic Stimulation TMS The excitability is suppressed in SCA patients due to corrupted brain areas and pathways
Motor learning is the process of obtaining the capability for movement Motor learning is not merely focusing on changes in performance during practice but also being evaluated during retention andor transfer Motor learning can be divided into explicit and implicit learning One type of implicit learning is the acquisition of motor skills often referred to as procedural learning Serial reaction time task SRTT is used to describe implicit sequence motor learning A series of implicit motor sequence learning tasks is to clarify the role and function of the cerebellum And this function is deficient in SCA patients
Priming is an unconscious process associated with learning to alter the later response by the proceeding stimulus Priming is applied to physical therapy it could result in behavioral change and strengthen the training effect afterward
Cycling could be an aerobic exercise priming that may help to raise brain blood flow and oxygenation facilitate synaptic plasticity augment the release of neurotrophic factors to transmit neuroendocrine and myokines
This project will advance the knowledge of the mechanism of motor performance and motor learning in SCA individuals The result of this project can be applied to the clinical rehabilitation of people with SCA
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None