Ignite Creation Date:
2024-05-06 @ 8:24 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06371820
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-04-17
First Post:
2024-03-27
Brief Title:
ESPRESSO Epidemiology Strengthened by histoPathology Reports in Sweden
Sponsor:
Karolinska Institutet
Organization:
Karolinska Institutet
Study Overview
Official Title:
ESPRESSO Epidemiology Strengthened by histoPathology Reports in Sweden
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ESPRESSO
Brief Summary:
The ESPRESSO study is a collection of data from all computerised gastrointestinal histopathology reports in Sweden This allows us to study risk factors for gastrointestinal disease as well as the prognosis of gastrointestinal disease
A review of the study has been published here
httpspubmedncbinlmnihgov30679926
A review of the study has been published here
httpspubmedncbinlmnihgov30679926
Detailed Description:
The ESPRESSO study constitutes a novel approach to examine the etiology and prognosis of gastrointestinal disease in which histopathology plays a prominent role Between 2015 and 2017 all pathology departments n28 in Sweden were contacted and asked to procure histopathology record data from the gastrointestinal tract pharynx to anus liver gallbladder and pancreas For each individual local histopathology IT personnel retrieved data on personal identity number date of histopathology topography where the biopsy is taken morphology biopsy appearance and where available free text In total between 1965 and 2017 histopathology record data were available in 21 million unique individuals but the number of data entries was 61 million because more than one biopsy was performed in many of the study participants Index individuals with histopathology data were matched with up to five controls from the general population The investigators also identified all first-degree relatives parents children full siblings and the index individuals first spouse The total study population consisted of 130 million individuals Data from all the study participants have been linked to Swedish National Healthcare Registers allowing research not only on such aspects as fetal and perinatal conditions and the risk of future gastrointestinal disease but also on the risk of comorbidity and complications including cancer and death Furthermore the ESPRESSO database allows researchers and practitioners to identify diagnoses and disease phenotypes not currently indexed in national registers including disease precursors The ESPRESSO database increases the sensitivity and specificity of already-recorded diseases in the national health registers This paper is an overview of the ESPRESSO database
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None