Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06375980
Status:
COMPLETED
Last Update Posted:
2024-04-19
First Post:
2024-04-17
Brief Title:
Intraoperative Mechanical Power and Ventilation-Associated Lung Injury Assessing Complications
Sponsor:
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Organization:
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Study Overview
Official Title:
The Relationship Between Intraoperative Mechanical Power Applied to The Lung and Postoperative Pulmonary Complications in Patients Undergoing Major Abdominal Surgery
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study investigates the relationship between intraoperative mechanical power and postoperative pulmonary complications in patients undergoing major abdominal surgery The investigators record mechanical ventilation parameters and surgical characteristics assessing the incidence of pulmonary complications within 24 hours postoperatively
Detailed Description:
Postoperative pulmonary complications PPCs are often underestimated yet remain a leading cause of perioperative morbidity and mortality These complications encompass postoperative hypoxia atelectasis bronchospasm pulmonary infections infiltrations aspiration pneumonia acute respiratory distress syndrome ARDS pleural effusion and pulmonary edema They are prevalent and associated with significant costs prolonging hospital stays ventilation duration and ICU admissions while also increasing mortality and morbidity risks
Perioperative mechanical ventilation stands as a primary risk factor for the development of postoperative pulmonary complications Approximately one in four patients with normal lungs will develop some form of lung injury following mechanical ventilation although much of this damage can be mitigated through the use of appropriate ventilation strategies A range of pulmonary complications induced by mechanical ventilation is known as ventilator-induced lung injury VILI
A growing understanding of the injury mechanism aids researchers in identifying risk factors for lung injury including tidal volume respiratory rate pressures and flow Mechanical power which combines tidal volume respiratory rate and airway pressure has been identified as a potential contributor to VILI The greater the power the higher the likelihood of lung injury occurring
Mechanical power represents the total energy expended over a specific period and is typically expressed in joules per minute Jmin The equation for mechanical power can help estimate the contribution of different causes of VILI and their variations This equation can be easily applied in the software of each ventilator Recent studies have investigated threshold values for mechanical power in relation to ventilator-associated lung injury using the simplified formula found for mechanical power
Perioperative mechanical ventilation stands as a primary risk factor for the development of postoperative pulmonary complications Approximately one in four patients with normal lungs will develop some form of lung injury following mechanical ventilation although much of this damage can be mitigated through the use of appropriate ventilation strategies A range of pulmonary complications induced by mechanical ventilation is known as ventilator-induced lung injury VILI
A growing understanding of the injury mechanism aids researchers in identifying risk factors for lung injury including tidal volume respiratory rate pressures and flow Mechanical power which combines tidal volume respiratory rate and airway pressure has been identified as a potential contributor to VILI The greater the power the higher the likelihood of lung injury occurring
Mechanical power represents the total energy expended over a specific period and is typically expressed in joules per minute Jmin The equation for mechanical power can help estimate the contribution of different causes of VILI and their variations This equation can be easily applied in the software of each ventilator Recent studies have investigated threshold values for mechanical power in relation to ventilator-associated lung injury using the simplified formula found for mechanical power
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None