Ignite Creation Date:
2024-05-06 @ 8:25 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06372613
Status:
RECRUITING
Last Update Posted:
2024-05-06
First Post:
2024-04-15
Brief Title:
Association Between LRG and Histologic Remission in Ulcerative Colitis
Sponsor:
Showa Inan General Hospital
Organization:
Showa Inan General Hospital
Study Overview
Official Title:
What is the Level of Serum Leucine-rich α 2-glycoprotein LRG Which Predicts Histologic Remission in Patients With Ulcerative Colitis
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We attempt to clarify the serum leucine-rich α 2-glycoprotein LRG level which can predict histologic remission in ulcerative colitis patients in this study Colonoscopy with histology will be performed when histologic remission is predicted irrespective of symptoms or serum LRG values Serum LRG levels are analyzed by an enzyme-linked immunosorbent assay
Detailed Description:
Aim Serum leucine-rich α 2-glycoprotein LRG may be a noninvasive biomarker for monitoring disease activity in patients with ulcerative colitis UC We attempt to clarify the LRG level which predicts histologic remission in UC patients in this study
Methods Patients with UC were consecutively enrolled with the measurement of serum LRG Colonoscopy with histology is performed when histologic remission is predicted irrespective of symptoms or serum LRG values Serum LRG levels are analyzed by an enzyme-linked immunosorbent assay For the evaluation of UC activity clinical remission was defined as score 1 or 0 using the partial Mayo score and endoscopic remission was defined as score 0 using the Mayo endoscopic subscore And histologic remission is defined as grade 2 using Geboes score We analyze the area under receiver operating characteristic ROC curves to evaluate the diagnostic ability of LRG for predicting histologic remission of UC
Methods Patients with UC were consecutively enrolled with the measurement of serum LRG Colonoscopy with histology is performed when histologic remission is predicted irrespective of symptoms or serum LRG values Serum LRG levels are analyzed by an enzyme-linked immunosorbent assay For the evaluation of UC activity clinical remission was defined as score 1 or 0 using the partial Mayo score and endoscopic remission was defined as score 0 using the Mayo endoscopic subscore And histologic remission is defined as grade 2 using Geboes score We analyze the area under receiver operating characteristic ROC curves to evaluate the diagnostic ability of LRG for predicting histologic remission of UC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None