Ignite Creation Date:
2024-05-06 @ 8:26 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06386796
Status:
RECRUITING
Last Update Posted:
2024-05-03
First Post:
2024-04-04
Brief Title:
Renal Resistive Index as a Predictor of Acute Renal Impairment in High-risk Patients
Sponsor:
Aswan University
Organization:
Aswan University
Study Overview
Official Title:
Renal Resistive Index as a Predictor of Acute Renal Impairment in High-risk Patients Admitted to Surgical Intensive Care Unit
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study the ability of RRI measured by bedside Doppler ultrasound in detecting acute kidney injury in high-risk patients admitted to surgical intensive care unit Aswan university hospital compared with renal biomarkers and conventional assessment using urine output and serum creatinine levels
Detailed Description:
Acute kidney injury AKI is a common clinical problem encountered in critically ill patients frequently in the setting of multiple organ failure and is an independent risk factor for increase hospital stay and mortality risk
Early-stage acute kidney injury was first assessed based on the risk injury failure loss and end-stage RIFLE criteria in 2004 and then by the Acute Kidney Injury Network AKIN criteria in 2007 The Kidney Disease Improving Global Outcomes KDIGO classification based on both the AKIN and RIFLE criteria was introduced in 2012 offering an assessment based on baseline creatinine and urine output
The best strategy in clinical practice is to identify AKI as early as possible reverse its cause and even improve the sequelae In the past decades several serum creatinine SCr-based classification systems have been proposed to define AKI
The limitations of SCr is that the determinants of SCr rate of production apparent volume of distribution and rate of elimination are variable Therefore there is an unmet need for other objective measures to help detect AKI in a timely manner The role of several biomarkers in the early prediction or risk assessment of AKI has been proposed including kidney tubular damage markers eg neutrophil gelatinase-associated lipocalin NGAL kidney injury molecule-1 KIM- 1 liver-type fatty acid-binding protein L-FABP and cystatin C
Cystatin C is a protein from the family of cysteine proteinase inhibitors and is of interest as an early marker of decreased renal function It is a protein that is synthesized at a constant rate by all cells containing nuclei secreted into biological fluids plasma pleural ascitic cerebrospinal fluid freely filtered through the glomerular membrane due to its low molecular weight fully metabolized in the kidneys not secreted by the proximal renal tubules
Renal resistive index RRI is a noninvasive instrument to evaluate kidney hemodynamics and it is obtained by analysis of intrarenal arterial waves using Doppler ultrasound
Early-stage acute kidney injury was first assessed based on the risk injury failure loss and end-stage RIFLE criteria in 2004 and then by the Acute Kidney Injury Network AKIN criteria in 2007 The Kidney Disease Improving Global Outcomes KDIGO classification based on both the AKIN and RIFLE criteria was introduced in 2012 offering an assessment based on baseline creatinine and urine output
The best strategy in clinical practice is to identify AKI as early as possible reverse its cause and even improve the sequelae In the past decades several serum creatinine SCr-based classification systems have been proposed to define AKI
The limitations of SCr is that the determinants of SCr rate of production apparent volume of distribution and rate of elimination are variable Therefore there is an unmet need for other objective measures to help detect AKI in a timely manner The role of several biomarkers in the early prediction or risk assessment of AKI has been proposed including kidney tubular damage markers eg neutrophil gelatinase-associated lipocalin NGAL kidney injury molecule-1 KIM- 1 liver-type fatty acid-binding protein L-FABP and cystatin C
Cystatin C is a protein from the family of cysteine proteinase inhibitors and is of interest as an early marker of decreased renal function It is a protein that is synthesized at a constant rate by all cells containing nuclei secreted into biological fluids plasma pleural ascitic cerebrospinal fluid freely filtered through the glomerular membrane due to its low molecular weight fully metabolized in the kidneys not secreted by the proximal renal tubules
Renal resistive index RRI is a noninvasive instrument to evaluate kidney hemodynamics and it is obtained by analysis of intrarenal arterial waves using Doppler ultrasound
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None