Ignite Creation Date:
2024-05-06 @ 8:26 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06386380
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-03
First Post:
2024-04-23
Brief Title:
Adversity and Its Association With the Development and Expression of Rheumatic Diseases
Sponsor:
National Institute of Medical Sciences and Nutrition Salvador Zubiran
Organization:
National Institute of Medical Sciences and Nutrition Salvador Zubiran
Study Overview
Official Title:
Adversity and Its Association With the Development and Expression of Rheumatic Diseases
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RD
Brief Summary:
Epidemiological evidence shows that adverse experiences particularly but not exclusively in childhood are predictors of poor long-term health outcomes and certain social domains In the field of rheumatic diseases traumatic events not only in childhood have been associated with hospitalization chronic pain inflammation worse outcomes severity of the disease and mortality Some mechanisms proposed to explain the association between the experience of adversity and the development of chronic diseases include an impact on the physiology of immune system cells gene expression due to DNA modification and cellular senescence
With this background the investigators wonder if for patients with rheumatoid arthritis the presence of adversity understood as a history of violence in childhood and abuse due to suffering from rheumatoid arthritis is associated with markers of cellular senescence and with the severity of illness
With this background the investigators wonder if for patients with rheumatoid arthritis the presence of adversity understood as a history of violence in childhood and abuse due to suffering from rheumatoid arthritis is associated with markers of cellular senescence and with the severity of illness
Detailed Description:
To answer this question the investigators proposed conducting a study on outpatients diagnosed with rheumatoid arthritis treated at the INCMNSZ
Patients who agree to participate will be asked to answer some questionnaires to report their perception of child abuse and abuse derived from suffering from rheumatoid arthritis disease activity disability quality of life anxiety stress depression and resilience
Additionally a peripheral blood sample will be taken to evaluate cellular senescence through CD27 CD28 and CD57 expression the relative expression of the p16INK4a gene in CD3 lymphocytes HLA-DR CD25 and CD69 and telomere length Finally the expression of the severity of the disease will be determined
Patients who agree to participate will be asked to answer some questionnaires to report their perception of child abuse and abuse derived from suffering from rheumatoid arthritis disease activity disability quality of life anxiety stress depression and resilience
Additionally a peripheral blood sample will be taken to evaluate cellular senescence through CD27 CD28 and CD57 expression the relative expression of the p16INK4a gene in CD3 lymphocytes HLA-DR CD25 and CD69 and telomere length Finally the expression of the severity of the disease will be determined
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None