Ignite Creation Date:
2024-05-06 @ 8:26 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06380998
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-24
First Post:
2024-04-16
Brief Title:
Effects of Petroleum Compounds on Psychological Health and Cognitive Functions
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Effects of Petroleum Compounds on Psychological Health Cognitive Functions and the Possible Ameliorating Effect of Whey Protein in a Sample of Petrol Station Workers in Assiut Governorate
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Over the last decade awareness of the effects of hydrocarbon fuels on neurodegenerative disorders has increased significantly as they are ubiquitous environmentally toxic chemicals that affect the central nervous system and result in irreversible neuronal damage as many hydrocarbons can cross the blood-brain barrier through multiple pathways and cause direct toxicity
Detailed Description:
Petrol stations are establishments that retail liquid fuels derived from petroleum alcohol and other automotive fuels with equipment available for their measurement and storage This process linked to gasoline distribution can be a significant source of volatile organic compounds VOCs such as benzene toluene ethylbenzene and xylene isomers BTEX the primary volatile hydrocarbons derived from petroleum
Headache fatigue dizziness respiratory tract infections skin allergies eye infections and impairment of memory have been experienced by a few people immediately following exposure to some solvents CNS depression is a common physiological outcome caused by high exposure to some VOCs General anaesthetic effects and as a most severe outcome unconsciousness and in some cases death may occur at the end
Long-term exposure to organic solvents may cause permanent central nervous system disturbances a condition called chronic solvent encephalopathy CSE
Cognitive symptoms and neuropsychological signs or issues with memory focus and learning are the hallmarks of CSE which is underdiagnosed and characterized by these symptoms as well as possible side effects like headaches fatigue balance issues and mild depression If exposure stops though the illness will not worsen
We are discovering more about the importance of nutrition and its impact on an individuals susceptibility to illness progression Diet has been suggested to have an important role in cognitive health and the development of dementia However most of the intervention studies conducted to date have mainly assessed the effect of dietary supplements on cognitive function
The toxicity of inhaled vapours is due to their biotransformation into reactive oxygen species and several studies have highlighted the capacity of whey protein to increase glutathione GSH suggesting that this complex mixture is capable of boosting GSH synthesis thus reducing oxidative stress
Headache fatigue dizziness respiratory tract infections skin allergies eye infections and impairment of memory have been experienced by a few people immediately following exposure to some solvents CNS depression is a common physiological outcome caused by high exposure to some VOCs General anaesthetic effects and as a most severe outcome unconsciousness and in some cases death may occur at the end
Long-term exposure to organic solvents may cause permanent central nervous system disturbances a condition called chronic solvent encephalopathy CSE
Cognitive symptoms and neuropsychological signs or issues with memory focus and learning are the hallmarks of CSE which is underdiagnosed and characterized by these symptoms as well as possible side effects like headaches fatigue balance issues and mild depression If exposure stops though the illness will not worsen
We are discovering more about the importance of nutrition and its impact on an individuals susceptibility to illness progression Diet has been suggested to have an important role in cognitive health and the development of dementia However most of the intervention studies conducted to date have mainly assessed the effect of dietary supplements on cognitive function
The toxicity of inhaled vapours is due to their biotransformation into reactive oxygen species and several studies have highlighted the capacity of whey protein to increase glutathione GSH suggesting that this complex mixture is capable of boosting GSH synthesis thus reducing oxidative stress
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None