Ignite Creation Date:
2024-05-06 @ 8:26 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06389058
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-04-29
First Post:
2024-04-24
Brief Title:
Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System
Sponsor:
San Diego State University
Organization:
San Diego State University
Study Overview
Official Title:
Using NLP and Neural Networks to Autonomously Identify Severe Asthma and Determine Study Eligibility in a Large Healthcare System
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aims to to use new technologies ML AI NLP to autonomously identify moderate to severe asthma populations within an EHR system describe differences in treatment patterns across different populations and determine trial eligibility
Primary Objectives Please ensure you detail primary objectives Aim 1 Determine and validate a diagnosis of severe asthma SA using predictive features obtained from the Scripps Health EHR
Aim 1a Use ML applied to structured EHR data to predict SA Use the opinion of 2 specialty-trained physicians and ATS guidelines to determine model accuracy
Aim 1b Use NLP applied to unstructured text to predict SA Determine model accuracy as above in Aim 1a
Aim 1c Use a combination of ML applied to structured data to predict SA Determine model accuracy as above in Aim 1a
Primary Objectives Please ensure you detail primary objectives Aim 1 Determine and validate a diagnosis of severe asthma SA using predictive features obtained from the Scripps Health EHR
Aim 1a Use ML applied to structured EHR data to predict SA Use the opinion of 2 specialty-trained physicians and ATS guidelines to determine model accuracy
Aim 1b Use NLP applied to unstructured text to predict SA Determine model accuracy as above in Aim 1a
Aim 1c Use a combination of ML applied to structured data to predict SA Determine model accuracy as above in Aim 1a
Detailed Description:
Asthma is a heterogeneous disease The heterogeneity of asthma is supported by clinical observations and genome wide association studies GWASs that have identified over 200 asthma susceptibility loci in the DNA These genetic hot spots are near inflammatory cytokines growth factors and other inflammatory proteins knowingly linked to airway inflammation including cytokines IL-4 -5 -13 -25 -33 and TSLP
Novel monoclonal antibody therapies have drastically changed the treatment of moderate-to-severe asthma Novel monoclonal antibody therapies introduced in the last 7 years have greatly advanced treatment options for moderate-to-severe asthma patients These therapies effectively reduce or eliminate severe exacerbations prevent hospitalizations and improve patients quality of life However many severe asthma patients particularly those living in underserved areas are still being overtreated with steroids and undertreated with monoclonal antibodies
The 21st Century Cures Act will Change the Landscape of Research The 21st Century Cures Act reinforced the use of real-world data RWD and real-world evidence RWE to support clinical trials aid in drug coverage decisions develop national treatment guidelines as well as standardized decision support tools An underutilized source of RWED are electronic health records EHR Machine Learning ML AI and natural language processing NLP are developing technologies that will greatly advance our ability to leverage data in EHR systems
The study aims to use new technologies ML AI NLP to autonomously identify moderate to severe asthma populations within an EHR system describe differences in treatment patterns across different populations and determine trial eligibility
Primary Objectives Please ensure you detail primary objectives Aim 1 Determine and validate a diagnosis of severe asthma SA using predictive features obtained from the Scripps Health EHR
Aim 1a Use ML applied to structured EHR data to predict SA Use the opinion of 2 specialty-trained physicians and ATS guidelines to determine model accuracy
Aim 1b Use NLP applied to unstructured text to predict SA Determine model accuracy as above in Aim 1a
Aim 1c Use a combination of ML applied to structured data to predict SA Determine model accuracy as above in Aim 1a
Novel monoclonal antibody therapies have drastically changed the treatment of moderate-to-severe asthma Novel monoclonal antibody therapies introduced in the last 7 years have greatly advanced treatment options for moderate-to-severe asthma patients These therapies effectively reduce or eliminate severe exacerbations prevent hospitalizations and improve patients quality of life However many severe asthma patients particularly those living in underserved areas are still being overtreated with steroids and undertreated with monoclonal antibodies
The 21st Century Cures Act will Change the Landscape of Research The 21st Century Cures Act reinforced the use of real-world data RWD and real-world evidence RWE to support clinical trials aid in drug coverage decisions develop national treatment guidelines as well as standardized decision support tools An underutilized source of RWED are electronic health records EHR Machine Learning ML AI and natural language processing NLP are developing technologies that will greatly advance our ability to leverage data in EHR systems
The study aims to use new technologies ML AI NLP to autonomously identify moderate to severe asthma populations within an EHR system describe differences in treatment patterns across different populations and determine trial eligibility
Primary Objectives Please ensure you detail primary objectives Aim 1 Determine and validate a diagnosis of severe asthma SA using predictive features obtained from the Scripps Health EHR
Aim 1a Use ML applied to structured EHR data to predict SA Use the opinion of 2 specialty-trained physicians and ATS guidelines to determine model accuracy
Aim 1b Use NLP applied to unstructured text to predict SA Determine model accuracy as above in Aim 1a
Aim 1c Use a combination of ML applied to structured data to predict SA Determine model accuracy as above in Aim 1a
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None