Ignite Creation Date:
2024-05-06 @ 8:26 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06385756
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-22
First Post:
2024-04-17
Brief Title:
Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions
Sponsor:
Tongji Hospital
Organization:
Tongji Hospital
Study Overview
Official Title:
Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions in Gynecological Laparoscopic Surgery
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
At present there are limited data on perioperative efficacy of barbiturates at home and abroad The purpose of this clinical trial is to observe the effects of amobarbital sodium combined with low-dose propofol on hemodynamics during induction and perioperative adverse reactions in gynecological laparoscopic surgery patients and to provide a more reasonable safe and comfortable anesthesia program for female patients who undergoing laparoscopic surgery
The main questions it aims to answer are
whether the combination of the two results on more stable hemodynamics during induction in gynecological laparoscopic surgery patients
whether the incidence of perioperative oxidative stress and inflammation and postoperative nausea and vomitingponv improved after the use of the two combinations of anesthesia induction
Participants will
Induction of anesthesia with the experimental drug or placebo
5 ml of venous blood was retained before after and 1 day after surgery for follow-up determination of serum associated factor levels
To record their vital signs at any point during the anaesthetic process Serum serological indexes related to oxidative stress and inflammation were determined The agitation during the recovery period was recorded The incidence and severity of ponv were recorded at 2h 2-6h and 6-24h postoperatively and the use of palonosetron was also recorded
The main questions it aims to answer are
whether the combination of the two results on more stable hemodynamics during induction in gynecological laparoscopic surgery patients
whether the incidence of perioperative oxidative stress and inflammation and postoperative nausea and vomitingponv improved after the use of the two combinations of anesthesia induction
Participants will
Induction of anesthesia with the experimental drug or placebo
5 ml of venous blood was retained before after and 1 day after surgery for follow-up determination of serum associated factor levels
To record their vital signs at any point during the anaesthetic process Serum serological indexes related to oxidative stress and inflammation were determined The agitation during the recovery period was recorded The incidence and severity of ponv were recorded at 2h 2-6h and 6-24h postoperatively and the use of palonosetron was also recorded
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None