Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06386770
Status:
RECRUITING
Last Update Posted:
2024-05-03
First Post:
2024-04-04
Brief Title:
Systemic Versus Local Dexmedetomidine as An Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Block
Sponsor:
Aswan University
Organization:
Aswan University
Study Overview
Official Title:
Systemic Versus Local Dexamedetomedine as An Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Block in Kidney Exploration Surgeries A Randomized Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to investigate the analgesic effect of local versus systemic dexamedetomedine as adjuvant to bupivacaine in erector spinae block in kidney exploration surgeries
Detailed Description:
Open Kidney surgeries remain one of the approaches used for those patients are requiring partial or radical nephrectomy and is associated with a high incidence of intense immediate postoperative pain and chronic pain for months following surgery
Effective treatment of postoperative pain allows early mobilization of the patient shortens the recovery and discharge time prevents the development of chronic pain and increases satisfaction and long-term quality of life
Current modalities used to manage pain for patients undergoing kidney exploration include oral and parenteral opioid administration local anesthetic infiltration and certain neuraxial and regional anesthesia procedures including thoracic epidurals and paravertebral blocks
The erector spinae plane ESP block is a newer regional anesthetic technique that can be used to provide analgesia for a variety of surgical procedures or to manage acute or chronic pain The technique is relatively easy to perform on patients and it is performable with minimal or no sedation in the pre-operative holding area
Ultrasound is a non-invasive visualization technology that helps capture the anatomical structure of target tissues it can help guide the direction and depth of anesthesia puncture needles thus reducing the risk of complications
The local anesthetic drugs have a limited duration of action so we need to add adjuvants such as opioids alpha two agonists neostigmine or magnesium
Dexmedetomidine is a potent α2 agonist and is a powerful adjuvant to regional anesthesia and analgesia It can prolong the duration of the nerve block anesthesia resulting in increased effectiveness of the block in terms of duration less use of opioids and shorter hospital stay in the absence of clinically significant side effects hypotension nausea vomiting and pruritus
Adding adjuvants to local anesthetics is frequently used to prolong the duration of single-injection regional nerve block
There have been multiple studies claiming increased effectiveness of use of dexmedetomidine and this has been consolidated in a meta-analysis examining the effectiveness of dexamedetomedine as a peripheral nerve block adjuvant
Effective treatment of postoperative pain allows early mobilization of the patient shortens the recovery and discharge time prevents the development of chronic pain and increases satisfaction and long-term quality of life
Current modalities used to manage pain for patients undergoing kidney exploration include oral and parenteral opioid administration local anesthetic infiltration and certain neuraxial and regional anesthesia procedures including thoracic epidurals and paravertebral blocks
The erector spinae plane ESP block is a newer regional anesthetic technique that can be used to provide analgesia for a variety of surgical procedures or to manage acute or chronic pain The technique is relatively easy to perform on patients and it is performable with minimal or no sedation in the pre-operative holding area
Ultrasound is a non-invasive visualization technology that helps capture the anatomical structure of target tissues it can help guide the direction and depth of anesthesia puncture needles thus reducing the risk of complications
The local anesthetic drugs have a limited duration of action so we need to add adjuvants such as opioids alpha two agonists neostigmine or magnesium
Dexmedetomidine is a potent α2 agonist and is a powerful adjuvant to regional anesthesia and analgesia It can prolong the duration of the nerve block anesthesia resulting in increased effectiveness of the block in terms of duration less use of opioids and shorter hospital stay in the absence of clinically significant side effects hypotension nausea vomiting and pruritus
Adding adjuvants to local anesthetics is frequently used to prolong the duration of single-injection regional nerve block
There have been multiple studies claiming increased effectiveness of use of dexmedetomidine and this has been consolidated in a meta-analysis examining the effectiveness of dexamedetomedine as a peripheral nerve block adjuvant
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None