Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06387225
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-08
First Post:
2024-04-18
Brief Title:
Early and Objective Assessment of Neurological Prognosis in Cardiac Arrest Patients
Sponsor:
Nantes University Hospital
Organization:
Nantes University Hospital
Study Overview
Official Title:
Early and Objective Assessment of Neurological Prognosis in Cardiac Arrest Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HYPERION-2
Brief Summary:
Cerebral lesions are responsible for two thirds of deaths in patients admitted to intensive care following cardiac arrest Patients with neurological lesions should be the priority target for neuroprotective interventions which are the cornerstone of post-cardiac arrest care allowing a reduction in the burden of care for patients without this type of lesion Furthermore these interventions must be based on a precise assessment of the severity of these brain lesions carrying out neuro-protective interventions in patients without brain lesions exposes these patients to unnecessary treatment potentially associated with adverse effects without any possible benefit However the early assessment of neurological prognosis particularly on admission to intensive care is an area where there is little research and where it is not possible to obtain a precise and reproducible assessment Several tools can be used to assess this prognosis at an early stage anamnesis and characteristics of the cardiac arrest and the patients comorbidities imaging electrophysiology and biomarkers
To assess the predictive value of early biomarker testing in patients resuscitated after cardiac arrest whatever the cause the investigators plan to conduct a prospective observational multicentre trial
It is important to bear in mind that the aim of this study is not to assess the long-term prognosis of patients suffering cardiac arrest in order to take measures to limit or discontinue active therapies but simply to provide a reliable tool simple and quick to use in order to be able to identify a sub-population of patients who should be the subject of preferential neuro-protection measures and conversely to simplify management moderate temperature control early cessation of sedation early extubation for patients with no neurological lesions
To assess the predictive value of early biomarker testing in patients resuscitated after cardiac arrest whatever the cause the investigators plan to conduct a prospective observational multicentre trial
It is important to bear in mind that the aim of this study is not to assess the long-term prognosis of patients suffering cardiac arrest in order to take measures to limit or discontinue active therapies but simply to provide a reliable tool simple and quick to use in order to be able to identify a sub-population of patients who should be the subject of preferential neuro-protection measures and conversely to simplify management moderate temperature control early cessation of sedation early extubation for patients with no neurological lesions
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None