Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06385106
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-25
First Post:
2024-04-08
Brief Title:
Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimers Disease
Sponsor:
First Affiliated Hospital of Zhejiang University
Organization:
First Affiliated Hospital of Zhejiang University
Study Overview
Official Title:
Effects of Repetitive Transcranial Magnetic Stimulation on Sleep and Cognitive Function in Patients With Alzheimers Disease a Randomized Double-blind Controlled Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Previous studies have shown that repetitive transcranial magnetic stimulation rTMS can improve cognitive function in Alzheimers disease AD but studies on the improvement of sleep disorders in AD are limited The aim of this study was to evaluate the effects of rTMS on sleep and cognition in patients with mild-to-moderate Alzheimers disease AD
Detailed Description:
Transcranial magnetic stimulation TMS is a non-invasive brain stimulation technique Some studies have showed that its positive effects in patients with Alzheimers disease The aim of this study was to evaluate the effect of rTMS on sleep and cognitive function in patients with mild to moderate AD and to evaluate the glymphatic system functions mediating role between sleep and cognitive function The study involves participants receiving 10 sessions of high frequency rTMS treatment applied to the dorsolateral prefrontal cortex over a 5 days period or sham rTMS Neuropsychological testing and polysomnography will be used as the primary outcome measures In addition magnetic resonance imaging will be used to explore the effect of rTMS on the glymphatic system function in patients with Alzheimers disease Follow-up assessments of the patients status will be conducted at one and three-month intervals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None