Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06385834
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-26
First Post:
2024-04-17
Brief Title:
The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction
Sponsor:
RenJi Hospital
Organization:
RenJi Hospital
Study Overview
Official Title:
The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the study was to intervene in the Aerobic exercise time of patients with STEMI and to explore the optimal exercise time for STEMI patients
Detailed Description:
Cardiovascular disease CVD remains the first cause of mortality worldwide More than 30 of CVD-connected fatalities are ascribed to ST-segment Elevation myocardial infarction STEMI There is strong and consistent evidence that aerobic exercise after a STEMI improves overall and cardiovascular-related mortality Aerobic exercise AE acts in key mechanisms of cardiac remodeling and function improvement after STEMI thus contributing both to prevent or postpone harmful adaptations and even to recover from negative alterations caused by cardiac ischemia However the time of day to exercise for STEMI patients optimal cardiac benefits is currently unknown
The circadian clock endows the host with temporal precision and robust adaptation to the surrounding environment Almost all physiologic metabolic and endocrine processes including glycolysis lipid and carbohydrate metabolism as well as cardiovascular function heart rate blood pressure are influenced by the circadian clock Recent investigations in rodents utilizing gain-of-functionloss-of-function models and in humans have identified Adverse cardiovascular events have daynight patterns is related to endogenous circadian clock control of platelet activation events Several studies have also demonstrated the effect of AE at different times on blood pressure Indeed timing is critical in amplifying the beneficial impact of AE However these studies did not address cardiac structural remodeling or other CVD-related metabolic markers it difficult to determine the physiological and structural effects of different time AE on cardiovascular health
Thus In this trial our aim is to assess in patients who have had an STEMI AE in which time of a day can give the best benefits to cardiac remodeling and function improvement
The circadian clock endows the host with temporal precision and robust adaptation to the surrounding environment Almost all physiologic metabolic and endocrine processes including glycolysis lipid and carbohydrate metabolism as well as cardiovascular function heart rate blood pressure are influenced by the circadian clock Recent investigations in rodents utilizing gain-of-functionloss-of-function models and in humans have identified Adverse cardiovascular events have daynight patterns is related to endogenous circadian clock control of platelet activation events Several studies have also demonstrated the effect of AE at different times on blood pressure Indeed timing is critical in amplifying the beneficial impact of AE However these studies did not address cardiac structural remodeling or other CVD-related metabolic markers it difficult to determine the physiological and structural effects of different time AE on cardiovascular health
Thus In this trial our aim is to assess in patients who have had an STEMI AE in which time of a day can give the best benefits to cardiac remodeling and function improvement
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None