Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:27 PM
Study NCT ID:
NCT06380725
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-24
First Post:
2024-04-15
Brief Title:
The Treatment of High Intensity Transcranial Current Stimulation for Alzheimers Disease
Sponsor:
Anhui Provincial Hospital
Organization:
Anhui Provincial Hospital
Study Overview
Official Title:
A Randomized Double-blind Placebo Controlled Trial of High Intensity Transcranial Current Stimulation in Patients With Alzheimers Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Alzheimers disease AD is a neurodegenerative disorder characterized by progressive cognitive dysfunction and behavioral impairment It is currently the most common type of dementia in the old age At present the clinical treatment of Alzheimers disease is expensive and has side effects so it is very important to explore new methods of treatment for AD Investigators designed a prospective randomized double-blinded and placebo-controlled trial to investigate the effect of transcranial alternating current stimulation tACS on cognitive function in AD patients and to assess the biological effectiveness of the treatment
Detailed Description:
As the population is aging there is an urgent need to develop new methods of treatment for AD Noninvasive neuro-regulation is a new technique in treating neuropsychiatric diseases It include transcranial magnetic stimulation traditional transcranial direct current stimulation traditional transcranial alternating current stimulation and etc Previously conventional transcranial direct current stimulation had shown inconsistent results in the treatment for AD This may be related to the low current density of traditional electrical stimulation in deep brain areas such as hippocampus and amygdala and leading to poor stimulation effect Compared with the traditional transcranial electrical stimulation technology the high intensity tACS greatly improves the current intensity so that the electric field intensity to the deep brain nucleus during stimulation is greatly increased and it avoids side effects such as burning sensation Therefore it could be used for AD patients However there are few clinical studies on high intensity tACS on AD so investigators designed a randomized double-blinded placebo-controlled trial to explore the effect of high-current tACS on AD At the same time multimodal functional brain imaging before and after treatment will be used to compare the changes of brain function activation and cerebral hemodynamics in AD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None