Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06390696
Status:
RECRUITING
Last Update Posted:
2024-04-30
First Post:
2024-04-25
Brief Title:
Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis
Sponsor:
Natural Resources Institute Finland
Organization:
Natural Resources Institute Finland
Study Overview
Official Title:
Biodiversity Interventions for Well-being - the Effect of Biodiversity Exposure on Atopic Dermatitis
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BIWE
Brief Summary:
The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss According to biodiversity hypothesis the main reason is urban lifestyle and reduced contact to microbial diversity Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood
Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis alters commensal microbiota and modifies immune regulation in children
Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis alters commensal microbiota and modifies immune regulation in children
Detailed Description:
Our specific aims are
To assess if exposure to microbial diversity reduces Eczema Area and Severity Index EASI and Patient-Oriented Eczema Measure POEM
Assess whether the sand play alters plasma cytokine profiles white blood cell distributions allergy specific IgE and commensal microbial communities on skin in saliva and gut
The investigators will recruit approximately 80 40 study subjects per treatment subjects with atopic dermatitis and aged between 2-5
To assess if exposure to microbial diversity reduces Eczema Area and Severity Index EASI and Patient-Oriented Eczema Measure POEM
Assess whether the sand play alters plasma cytokine profiles white blood cell distributions allergy specific IgE and commensal microbial communities on skin in saliva and gut
The investigators will recruit approximately 80 40 study subjects per treatment subjects with atopic dermatitis and aged between 2-5
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None