Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06396390
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-02
First Post:
2024-04-29
Brief Title:
Comparison of Progestin Primed Ovarian Stimulation PPOS vsGnRH Antagonist Methods on IVF Outcomes
Sponsor:
Nesta Clinic
Organization:
Nesta Clinic
Study Overview
Official Title:
The Comparative Results of Progestin Primed Ovarian Stimulation PPOS and GnRH Antagonist Ovarian Stimulation Methods on IVF Outcomes
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this randomized clinical trial is to compare the effects of two different ovarian stimulation methods Progestin Primed Ovarian Stimulation PPOS vs GnRH Antagonist in embryologic outcomes of IVF Patients
Detailed Description:
The goal of this randomized clinical trial is to compare the effects of two different ovarian stimulation methods Progestin Primed Ovarian Stimulation PPOS vs GnRH Antagonist in embryologic outcomes of IVF Patients
Ovarian stimulation will be conducted according to the assigned arm protocol
Both artificially prepared and modified natural cycles will be eligible to be included and the choice will be done according to the doctors preference and the patients menstrual cycle regularity
For artificially prepared transfers Estradiol Hemihydrate Estrofem 2mg Novo Nordisk MalovDenmark 3x1 PO will be started on the day 2 of the menstrual cycle After 12-14 days of usage in order not to cancel the cycle endometrial thickness needs measured at least 7mm and serum progesterone level 15 ngmL
For luteal support in addition to Progesterone Progestan Dex 25mg Kocak Farma İlaç ve Kimya Sanayi AŞ Istanbul Turkiye 2x1 SC once with a 12-hour interval at day 14 of the menstrual cycle Progesterone Progestan 200mg Kocak Farma İlaç ve Kimya Sanayi AŞ Istanbul Turkiye 2x1 PV will be started and continued for 5 days Embryo transfer will be performed at 6th day Estradiol Hemihydrate will be stopped on week 2 and progesterone support will be continued until the 8th week of gestation
Ovarian stimulation will be conducted according to the assigned arm protocol
Both artificially prepared and modified natural cycles will be eligible to be included and the choice will be done according to the doctors preference and the patients menstrual cycle regularity
For artificially prepared transfers Estradiol Hemihydrate Estrofem 2mg Novo Nordisk MalovDenmark 3x1 PO will be started on the day 2 of the menstrual cycle After 12-14 days of usage in order not to cancel the cycle endometrial thickness needs measured at least 7mm and serum progesterone level 15 ngmL
For luteal support in addition to Progesterone Progestan Dex 25mg Kocak Farma İlaç ve Kimya Sanayi AŞ Istanbul Turkiye 2x1 SC once with a 12-hour interval at day 14 of the menstrual cycle Progesterone Progestan 200mg Kocak Farma İlaç ve Kimya Sanayi AŞ Istanbul Turkiye 2x1 PV will be started and continued for 5 days Embryo transfer will be performed at 6th day Estradiol Hemihydrate will be stopped on week 2 and progesterone support will be continued until the 8th week of gestation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None