Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06390930
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-04-30
First Post:
2024-04-24
Brief Title:
Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS
Sponsor:
Shirley Ryan AbilityLab
Organization:
Shirley Ryan AbilityLab
Study Overview
Official Title:
Investigating the Effects of Acute Intermittent Hypoxia on Neuroplasticity in Persons With Multiple Sclerosis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study seeks to explore changes in the neural pathways and arm function following a breathing intervention in the multiple sclerosis MS population The breathing intervention known as Acute Intermittent Hypoxia AIH involves breathing brief bouts of low levels of oxygen Research has found AIH to be a safe and effective intervention resulting in increased ankle strength in people with MS Here the study examines arm and hand function before and after AIH In order to better understand the brain and spinal cord response to AIH the investigators will measure muscle response and signals sent from the brain to the arm muscles before and after AIH
Detailed Description:
While AIH has shown potential in enhancing neuroplasticity in people with spinal cord injury SCI it has yet to be studied extensively in MS Preliminary research in the MS population demonstrates that a single session of AIH enhances motor output increasing voluntary muscle strength by as much as 15-20 within 60 minutes This study will explore potential mechanisms of AIH in MS using measurements of arm function as well as examination of corticospinal and spinal motoneuron excitability
Over the past decade studies have found that brief episodes of modest oxygen reduction termed AIH can rapidly enhance neural plasticity in persons with incomplete SCI AIH activates the serotonergic pathway leading to increased activity of serotonin receptors and the synthesis of plasticity-related proteins This plasticity is manifested by a rapid increase in voluntary muscle strength emerging within 60-90 minutes in both lower- and upper-limb muscles The actions of AIH appear to be biologically linked to systems designed to preserve breathing systems that are impaired by damage to the central nervous system CNS
Over the past decade studies have found that brief episodes of modest oxygen reduction termed AIH can rapidly enhance neural plasticity in persons with incomplete SCI AIH activates the serotonergic pathway leading to increased activity of serotonin receptors and the synthesis of plasticity-related proteins This plasticity is manifested by a rapid increase in voluntary muscle strength emerging within 60-90 minutes in both lower- and upper-limb muscles The actions of AIH appear to be biologically linked to systems designed to preserve breathing systems that are impaired by damage to the central nervous system CNS
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None