Ignite Creation Date:
2024-05-06 @ 8:27 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06392425
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-01
First Post:
2024-04-26
Brief Title:
Role of Serum ADAM 17 A Disintegrin And Metalloprotease 17 and Caspase 3 in Patients With Chronic Kidney Disease
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Role of Serum ADAM 17 A Disintegrin And Metalloprotease 17 and Caspase 3 in Patients With Chronic Kidney Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 To evaluate clinical utility of Serum ADAM 17 A disintegrin and metalloprotease 17 and Caspase 3 measurement in chronic kidney disease patients
2 Study relationship of serum ADAM 17 and Caspase 3 to stages of chronic kidney disease
3 Compare serum ADAM 17 and Caspase 3 levels in Diabetic Chronic kidney disease patients and Non Diabetic Chronic kidney disease patients
2 Study relationship of serum ADAM 17 and Caspase 3 to stages of chronic kidney disease
3 Compare serum ADAM 17 and Caspase 3 levels in Diabetic Chronic kidney disease patients and Non Diabetic Chronic kidney disease patients
Detailed Description:
Kidney diseases represent a global public health problem It is estimated that 10-15 of the population is affected by Chronic kidney disease1 Chronic kidney disease CKD is defined by persistent urine and structural abnormalities or impaired excretory renal function an estimated glomerular filtration rate eGFR less than 60 mlmin173 m2 persisting for three months or more suggestive of a loss of functional nephrons 2 the most common contributing factors to CKD include genetic abnormalities and ageing while the most common underlying diseases associated with CKD are diabetes and hypertension However CKD can be also due to infectious diseases autoimmune diseases such as lupus and medications 3 A disintegrin and metalloproteinase ADAM 17 also known as tumour necrosis factor α-converting enzyme TACE is a metalloproteinase that releases the ectodomains of most growth factors cytokines receptors and enzymes and has been associated with the presence of chronic kidney disease 5 Clinical and experimental studies have shown that ADAM17 is involved in chronic kidney disease CKD with a proinflammatory and profibrotic role suggesting that it could be an important mediator of CKD progression ADAM17 inhibition attenuates fibrosis and inflammation suggesting that its inhibition may be a possible new valuable therapeutic tool in fibrotic kidney disease treatment6 Caspases cysteine aspartases cysteine-aspartic proteases are protease enzymes which play a role in apoptotic pathway Their name derives from their specific cysteine protease activity Most cells have caspases in an inactive proenzyme form which is activated and induces other pro-caspases thus initiating a protease cascade This process is able to amplify the apoptotic signaling pathway and to induce rapid cell death Caspase-3 plays a dominant role in apoptosis involved in the pathogenesis and progression of chronic kidney disease CKD7
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None