Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06397248
Status:
RECRUITING
Last Update Posted:
2024-05-28
First Post:
2024-04-29
Brief Title:
DeVEnIR Defining Vulvovaginal Candidiasis - Elements of Infection and Remedy
Sponsor:
University Hospital Antwerp
Organization:
University Hospital Antwerp
Study Overview
Official Title:
DeVEnIR Defining Vulvovaginal Candidiasis - Elements of Infection and Remedy
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DeVEnIR
Brief Summary:
Female-specific health conditions are underrepresented in research The taboo felt by women to talk about intimate wellbeing is fed by this gender gap in scientific knowledge This project aims to meet these needs by studying one of the most prevalent female-specific infections vulvovaginal candidiasis VVC and paving the way towards its efficient diagnosis and treatment About 70 of women worldwide suffer from vaginal candidiasis at least once in their life An episode of this fungal infection is accompanied by a burning sensation pain and reduced mental well-being Some women about 5 encounter such infections at least four times a year referring to recurrentR VVC The design of efficient diagnostic and therapeutic strategies for RVVC is hindered by a knowledge gap surrounding vaginal health To meet the absolute need for more information this project will characterize the role of the microbiome metabolome immune system and pathogen characteristics in RVVC To this end a large sampling platform of women withwithout VVC will be established in this project The researchers will identify the most important and clinically relevant microorganisms metabolites and immune factors in VVC pathogenesis VVC models will be developed and optimized which will be used to validate the causality of the correlations identified in the cohort Identified correlations will be proposed as biomarkers and microbes metabolites and combinations which effectively lower the pathogenicity of Candida species will be further investigated for therapeutic potential State-of-the-art tools and know-how of the researchers will allow the unraveling of the involved molecular pathways and elucidate how these can be exploited to optimize therapeutic efficacy Finally the knowledge gathered in this project will be used to improve the literacy of women on VVC using platforms established by the researchers as well as novel tools to be developed in this project
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| S006424N | OTHER_GRANT | None | None |
| 5863 | OTHER | Project ID - Ethical Committee UZA | None |