Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06390631
Status:
COMPLETED
Last Update Posted:
2024-07-10
First Post:
2024-04-25
Brief Title:
Effect of CPAP on Respiratory Load in COPD
Sponsor:
State Key Laboratory of Respiratory Disease
Organization:
State Key Laboratory of Respiratory Disease
Study Overview
Official Title:
Effect of CPAP on Respiratory Load and Lung Volume in Stable COPD
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Both intrinsic positive end expiratory pressure PEEPi and dynamic hyperinflation are considered as inspiratory loads which increase work of breathing in patients with COPD The application of extrinsic positive end expiratory pressure PEEPe supplied by CPAP has been claimed to reduce inspiratory load based on change in esophageal pressure which could be significantly affected by change in lung volume and airflow The investigator hypothesized that CPAP could increase respiratory load because it increases lung volume
Detailed Description:
Objective To assess the effect of CPAP on respiratory load and lung volume in stable COPD Methods Patients with COPD were recruited to breath under the atmosphere pressure and different levels of CPAP 4 6 8 and 10 cm H2O Diaphragm EMG esophageal pressure Pes and transdiaphragmatic pressure Pdi were recorded using balloon esophageal electrode catheter Yinghui Guangzhou China End inspiratory lung volume EILV was measured directly from a pneumotachograph combined with a three way valve under the different CPAP levels Sensation of breathing difficulty was also assessed In an additional study the effect of airflow on pressure was investigated by a physical mode
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None