Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06392373
Status:
COMPLETED
Last Update Posted:
2024-04-30
First Post:
2024-04-25
Brief Title:
High Altitude Muscle Recovery
Sponsor:
United States Army Research Institute of Environmental Medicine
Organization:
United States Army Research Institute of Environmental Medicine
Study Overview
Official Title:
Skeletal Muscle Recovery From Aerobic Exercise During Acute High Altitude Exposure When Consuming Carbohydrate Compared to Carbohydrate Plus Protein
Status:
COMPLETED
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HAMR
Brief Summary:
To understand alterations in glycogen and molecular regulation of skeletal muscle glucose uptake glycogen synthesis and muscle protein recovery when consuming CHO glucose or CHOPRO glucose whey post-exercise during unacclimatized high altitude exposure randomized crossover double blinded studies will be conducted in the hypobarichypoxic chamber at USARIEM Table 1 Briefly the study consists of a 2 day baseline period at SL followed by two 3 day trial periods with the 3rd day being a testing day at HA The baseline is separated from trial 1 for a least a day and trial 1 2 separated by at least 4 days Volunteers will consume CHO glucose or CHOPRO glucose whey drinks post-exercise during unacclimatized high altitude exposure during the two trial periods The order of the drinks will be randomized using a random number generator such as randomizerorg and kept by a study staff not directly involved in data collection to maintain blinding
Detailed Description:
Dietary strategies that restore muscle glycogen and promote muscle repair and remodeling in recovery from exercise are needed to protect muscle mass and sustain performance during strenuous military operations conducted at high altitude HA 2500 m elevation However most military personnel who operate at HA are native lowlanders and thus unacclimatized to the hypoxemia that occurs upon initial HA exposure We demonstrated that acute HA exposure within 5 hours dysregulates peripheral glucose uptake and inhibits post-exercise muscle anabolism in lowlanders sojourning at 4300 m Our results suggest that traditional recommendations to consume solely carbohydrate immediately post-exercise to facilitate muscle recovery may be inadequate for lowlanders exercising within the first several hours of HA exposure In a recent meta-analysis by our group we reported that the effects of ingesting carbohydrate CHO compared to isocaloric carbohydrate plus protein CHOPRO on muscle glycogen repletion were equivocal yet the combined macronutrient blend confers an additional metabolic advantage than CHO alone because it stimulates muscle repairremodeling by upregulating anabolic signaling and protein synthesis Our findings suggest post-exercise CHO intake can be reduced in place of an isocaloric amount of PRO when exercising at HA without comprising glycogen repletion However whether CHOPRO promotes post-exercise glycogen repletion and muscle anabolism as compared to CHO alone when peripheral glucose uptake and anabolic signaling are dysregulated with acute HA exposure has not been determined This study aims to determine the effects of ingesting CHO or an isocaloric amount of CHOPRO post-aerobic exercise on glycogen synthesis molecular regulation of glucose uptake storage and muscle protein synthesis during acute HA exposure This study will employ a randomized crossover double-blinded design and be conducted in the hypobarichypoxic chamber at USARIEM A total of 10 healthy physically active men and women between the ages of 18-39 years will be studied Following 48 hours of controlled exercise and diet to normalize muscle glycogen stores volunteers will report to the laboratory after a 10-h overnight fast After a muscle biopsy is taken from the vastus lateralis at baseline volunteers will be brought to HA 460 mmHg conditions within the hypobarichypoxic chamber at USARIEM and complete a standardized glycogen depletion protocol on a cycle ergometer After completing the glycogen depletion exercise a second muscle biopsy will be taken Volunteers will then consume 12 g CHOkgh or 09 g CHOkgh 03 g PROkgh over a 3-h recovery period A third and fourth biopsy will be taken 4 and 6 hours into recovery to characterize the molecular regulation of glucose uptake glycogen synthesis and muscle protein synthesis over time Serial blood draws will be collected during each trial to assess endocrine and circulating substrate responses in CHO and CHOPRO Trials will be separated by a minimum of 4 days The primary risks associated with this study include those associated with acute hypobaric hypoxia exercise muscle biopsies and blood draws
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None